polymorphism | factor | odds ratio | pvalue | initial number | replication number | Population | age of cases | shorter lived allele | longer lived allele | study type | reference |
rs1801274 | FCGR2A | — | 1.0 | 408 vs 446 vs 454 | — | German | Centenarians | — | — | Candidate Region/Gene | 16893392 |
- | HRAS1 | — | 0.05 | see notes; stratified by population; total = 1321 cases versus 1140 controls | 1 (specifically for SIRT3 in a French population) | French, German, Italian | centenarians; see notes | — | — | - | 19367319 |
- | SIRT3 | — | 0.145 | see notes; stratified by population; total = 1321 cases versus 1140 controls | — | French, German, Italian | centenarians; see notes | — | — | - | 19367319 |
- | TH | — | 0.05 | see notes; stratified by population; total = 1321 cases versus 1140 controls | — | French, German, Italian | centenarians; see notes | — | — | - | 19367319 |
- | INS | — | 0.05 | see notes; stratified by population; total = 1321 cases versus 1140 controls | — | French, German, Italian | centenarians; see notes | — | — | - | 19367319 |
- | IGF2 | — | 0.05 | see notes; stratified by population; total = 1321 cases versus 1140 controls | — | French, German, Italian | centenarians; see notes | — | — | - | 19367319 |
56 SNPs - CYP2C gene family | CYP2C gene family: CYP2C8, CYP2C9, CYP2C18, CYP2C19 | — | 1.0 | 1,384 vs 945 | — | German | Mean age 98.8 | — | — | Candidate Region/Gene | 21798861 |
C4L*Q0 | — | — | 0.003 | 700 vs 900 | — | German | 94+ | — | — | Candidate Region/Gene | 24465950 |
length (STR polymorphism) | TH | — | 1.0 | 196 vs 358 | 471 vs 462 | German | (in replication) 96-110 years | — | — | Candidate Region/Gene | 21407269 |
rs1007991 | SOD3 | — | 0.679 | 1612 vs 1104 | — | German | 90+ | — | — | Candidate Region/Gene | 24163049 |
rs1041740 | SOD1 | — | 0.998 | 1612 vs 1104 | — | German | 90+ | — | — | Candidate Region/Gene | 24163049 |
rs1056836 | CYP1B1 | 0.63 | 0.78 | 205 vs 294 | — | German | 80-89; reference group: 17-79 | — | — | - | 15177664 |
rs1078892 | FOXO1 | 0.96 | 0.589 | 1447 vs 1029 (German) | 166 vs 216 (Italian) | German | — | — | — | Candidate Region/Gene | 21388494 |
rs10959258 | — | 1.36 | 1.86e-05 | 763 vs 1085 | 754 vs 850 | German | Mean age 99.7 | — | — | Genome-Wide Association Study | 21740922 |
rs10997870 | SIRT1 | — | 1.0 | 386 vs 640 vs 547 | — | German | Mean age 101 | — | — | Candidate Region/Gene | 16257164 |
rs11040489 | KRTAP5-6 | — | 0.05 | see notes; stratified by population; total = 1321 cases versus 1140 controls | — | French, German, Italian | centenarians; see notes | — | — | - | 19367319 |
rs11040489 | KRTAP5-6 | — | 0.005869 | 1600 samples (cases and controls combined) | — | German, Italian | — | — | — | Candidate Region/Gene | 19367319 |
rs11188059 | CYP2C | — | 0.04 | 616 centenarians versus control group of 945 younger individuals | — | German | — | — | — | Candidate Region/Gene | 21798861 |
rs11209971 | FOXO6 | 0.94 | 0.336 | 1447 vs 1029 (German) | 166 vs 216 (Italian) | German | Mean age 98.8 | — | — | Candidate Region/Gene | 21388494 |
rs1130214 | AKT1 | 0.97 | 0.544 | 2996 vs 1840 | — | Danish, German | 92-110 | — | — | Candidate Region/Gene | 22929028 |
rs11581271 | FOXO6 | 0.91 | 0.131 | 1447 vs 1029 (German) | 166 vs 216 (Italian) | German | Mean age 98.8 | — | — | Candidate Region/Gene | 21388494 |
rs11585393 | FOXO6 | 1.04 | 0.531 | 1447 vs 1029 (German) | 166 vs 216 (Italian) | German | Mean age 98.8 | — | — | Candidate Region/Gene | 21388494 |
rs11790055 | — | 1.38 | 1.49e-05 | 763 vs 1085 | 754 vs 850 | German | Mean age 99.7 | — | — | Genome-Wide Association Study | 21740922 |
rs12013673 | FOXO4 | 0.98 | 0.696 | 1447 vs 1029 (German) | 166 vs 216 (Italian) | German | Mean age 98.8 | — | — | Candidate Region/Gene | 21388494 |
rs12200646 | FOXO3 | 1.28 | 0.064 | 388 vs 371 | 535 vs 553 | German | mean age 98.4 years | — | — | Candidate Region/Gene | 19196970 |