polymorphism | factor | odds ratio | pvalue | initial number | replication number | Population | age of cases | shorter lived allele | longer lived allele | study type | reference |
rs11136000 | CLU | — | 0.975 | 1364 | — | American, British | Age range 50-108; mean age at death 80.2 | A | G | Candidate Region/Gene | 22445811 |
rs11767557 | EPHA1 | — | 0.267 | 1364 | — | American, British | Age range 50-108; mean age at death 80.2 | G | A | Candidate Region/Gene | 22445811 |
rs1485780 | CD2AP | — | 0.604 | 1364 | — | American, British | Age range 50-108; mean age at death 80.2 | C | A | Candidate Region/Gene | 22445811 |
rs1801274 | FCGR2A | — | 1.0 | 408 vs 446 vs 454 | — | German | Centenarians | — | — | Candidate Region/Gene | 16893392 |
rs3764650 | ABCA7 | — | 0.135 | 1364 | — | American, British | Age range 50-108; mean age at death 80.2 | C | A | Candidate Region/Gene | 22445811 |
rs3818361 | CR1 | — | 0.563 | 1364 | — | American, British | Age range 50-108; mean age at death 80.2 | G | A | Candidate Region/Gene | 22445811 |
rs3851179 | PICALM | — | 0.227 | 1364 | — | American, British | Age range 50-108; mean age at death 80.2 | G | A | Candidate Region/Gene | 22445811 |
rs3865444 | CD33 | — | 0.442 | 1364 | — | American, British | Age range 50-108; mean age at death 80.2 | C | A | Candidate Region/Gene | 22445811 |
rs610932 | MS4A6A | — | 0.176 | 1364 | — | American, British | Age range 50-108; mean age at death 80.2 | C | A | Candidate Region/Gene | 22445811 |
rs744373 | BIN1 | — | 0.689 | 1364 | — | American, British | Age range 50-108; mean age at death 80.2 | A | G | Candidate Region/Gene | 22445811 |
SLC6A4 | SLC6A4 | — | 1.0 | 224 vs 441 | — | Ashkenazi Jewish | 75 | — | — | Candidate Region/Gene | 15621215 |
(HLA)-A1, B8, DR3 | — | — | 1.0 | 93 vs 100 | — | Irish | 80-97 years | — | — | Candidate Region/Gene | 12714268 |
(rs429358, rs7412) + (rs2075650) | APOE + TOMM40 | 0.93 | 0.337 | 403 vs 1670 | 3746 vs 5912 | Dutch | Mean age 94 | e4 + G | — | Genome-Wide Association Study | 21418511 |
- | HRAS1 | — | 0.05 | see notes; stratified by population; total = 1321 cases versus 1140 controls | 1 (specifically for SIRT3 in a French population) | French, German, Italian | centenarians; see notes | — | — | - | 19367319 |
- | SIRT3 | — | 0.145 | see notes; stratified by population; total = 1321 cases versus 1140 controls | — | French, German, Italian | centenarians; see notes | — | — | - | 19367319 |
- | TH | — | 0.05 | see notes; stratified by population; total = 1321 cases versus 1140 controls | — | French, German, Italian | centenarians; see notes | — | — | - | 19367319 |
- | INS | — | 0.05 | see notes; stratified by population; total = 1321 cases versus 1140 controls | — | French, German, Italian | centenarians; see notes | — | — | - | 19367319 |
- | IGF2 | — | 0.05 | see notes; stratified by population; total = 1321 cases versus 1140 controls | — | French, German, Italian | centenarians; see notes | — | — | - | 19367319 |
- | GSTM1 | — | 0.54 | 66 vs 150 | — | Italian | 100.19±2.2 (95-105) | — | — | Candidate Region/Gene | 15195682 |
- | GSTM1 | — | 0.74 | 94 vs 418 | — | Italian | 100 years vs 46 years | — | — | - | 11162685 |
- | PARP1 | — | 1.0 | 239 vs 198 | — | French | >100 | — | — | Candidate Region/Gene | 9587069 |
-1377G/A | FAS | — | 0.106 | 50 vs 86 | — | Italian | 100.8 ± 1.8 (100 to 106) | — | — | Candidate Region/Gene | 11965496 |
-330T/G | IL2 | 1.43 | 0.096 | 168 vs 214 | — | Italian | >99 | — | — | Candidate Region/Gene | 16518704 |
-351A/G | ESR1 | — | 0.05 | 148 vs 414 | — | Polish | 99.6-107.2; mean= 101.1±1.2 | — | — | Candidate Region/Gene | 20599431 |
-397T/C | ESR1 | — | 0.06 | 149 vs 414 | — | Polish | 99.6-107.2; mean= 101.1±1.3 | — | — | Candidate Region/Gene | 20599431 |