Denigma Buck Institute Health Extension

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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
rs2476601 PTPN22 — 0.663 225 vs 278 — Italian Mean age 93 — — Candidate Region/Gene 21113673
rs1801133 MTHFR — 0.01 108 (patients with CVD) vs 118 — Swiss >65 C — Candidate Region/Gene 10583447
rs5882 CETP — 0.318 175 vs 189 — Italian 99.6 — — Candidate Region/Gene 15888337
rs2282679 GC — 0.6 1038 vs 461 — Dutch 59.5 years (offspring of nonagerians) — — Candidate Region/Gene 23128285
rs132793 XRCC6 — 0.74 224 vs 293 170 vs 220 Caucasian, European 90-103, 98+ (replication) — — Candidate Region/Gene 21972126
rs2234693 ESR1 — 0.08 108 vs 85 — Italian 90+ PP (genotype) — Candidate Region/Gene 20819792
rs1800795 IL6 — 0.006 244 vs 309 138 vs 98 Italian 85+ CC (genotype) — Candidate Region/Gene 19377912
rs1937 TFAM — 0.003 107 vs 284 — Spaniard 100–111 G CC (genotype) Candidate Region/Gene 23186209
rs708272 CETP — 0.068 523 vs 498 — Chinese Mean age 93.4 — — Candidate Region/Gene 22336474
rs6457452 HSP70-A1B — 1.0 347 vs 238 — American, Ashkenazi Jewish Minimum age 100 — — Candidate Region/Gene 17027907
rs5882 CETP — 0.05 300 vs 320 vs 258 — Ashkenazi Jewish Minimum age 95 AA, AG GG Candidate Region/Gene 15621216
rs1799782 XRCC1 — 0.658 430 vs 290 — British Mean age 70 — — Candidate Region/Gene 16518718
rs25487 XRCC1 — 0.51 430 vs 290 — British Mean age 70 — — Candidate Region/Gene 16518718
rs861539 XRCC3 — 0.97 430 vs 290 — British Mean age 70 — — Candidate Region/Gene 16518718
rs28360135 XRCC4 — 0.29 430 vs 290 — British Mean age 70 — — Candidate Region/Gene 16518718
rs1800896 IL10 — 0.019 174 vs 227 — Italian >100 — GG Candidate Region/Gene 12676903
rs1799945 HFE — 0.008 57 vs 60 — Italian 100-105 — — Candidate Region/Gene 12714263
rs4880 SOD2 — 0.009 224 vs 441 — Ashkenazi Jewish 75 C T Candidate Region/Gene 15621215
rs11039149 NR1H3 — 0.015 599 — Dutch 85 years haplotype 1 haplotype 2 Candidate Region/Gene 17452725
rs1800629 TNF — 1.0 174 vs 224 — Italian >100 — — Candidate Region/Gene 12676903
rs9340799 ESR1 — 1.0 148 vs 414 — Polish mean age 101.1 — — Candidate Region/Gene 20599431
rs1800587 IL1A — 0.31 250 vs 400 — Finn >90 — — Candidate Region/Gene 11640949
rs16944 IL1B — 0.08 250 vs 400 — Finn >90 — — Candidate Region/Gene 11640949
rs1143634 IL1B — 0.53 250 vs 400 — Finn >90 — — Candidate Region/Gene 11640949
rs1800795 IL6 — 0.23 250 vs 400 — Finn >90 — — Candidate Region/Gene 11640949
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  • 25 of 375 variants