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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
e4 APOE 0.55 0.03 163 vs 1039 Spanish 100+ e4 Candidate Region/Gene 24534555
e4 APOE 0.41 0.05 79 vs 597 Italian 100+ e4 Candidate Region/Gene 24534555
e4 APOE 0.35 0.001 729 vs 498 Japanese 100+ e4 Candidate Region/Gene 24534555
e4 APOE 0.04 376 vs 376 Canadian 85+ e4 Candidate Region/Gene 24126160
apoE haplotypes APOE 0.013 35 old vs 71 young vs 54 MI patients Chinese 90+ apoE4 Candidate Region/Gene 11780357
LPA isoform LPA 0.05 84 (cases) vs 517 Japanese 80+ Lp(a)F, Lp(a)B Candidate Region/Gene 11269751
apoE haplotypes APOE 0.013 35 old vs 71 young vs 54 MI patients Chinese 90 apoE4 Candidate Region/Gene 11780357
rs1800591-rs61733139 MTTP 0.61 197 vs 251 Dutch Mean age 93.8±3.1 Candidate Region/Gene 16611701
rs1800591-rs61733139 MTTP 0.46 655 vs 244 Dutch Mean age 87.5±3.1 Meta-Analysis 16611701
HP*1 F/S HP 0.82 0.33 1072 total Italian >88 Candidate Region/Gene 21147083
rs2234693 - rs2234693 ESR1 0.12 108 vs 85 Italian 90+ Candidate Region/Gene 20819792
APOE polymorphism APOE 0.437 1408 cases Brazilian 69.3 +/- 7.2 Candidate Region/Gene 17934638
APOE polymorphism - HP1/2 common polymorphism APOE 0.013 200 (cases) vs 539 (initial) Italian >88 e4-H2 (haplotype) Candidate Region/Gene 21703254
HP1/2 common polymorphism HP 0.05 200 (cases) vs 539 (initial) (initial) Italian >88 Candidate Region/Gene 21703254
Haplogroup J 0.38 0.025 98 vs 117 Chinese 90–100 Candidate Region/Gene 18759861
5178A,10400T mtDNA 0.387 463 vs 1389 Chinese >/=95 Mitochondrial Haplogroup 19641616
3010A,5178A,10400T mtDNA 0.141 463 vs 1389 Chinese >/=95 Mitochondrial Haplogroup 19641616
14979C,3010A,5178A,10400T mtDNA 0.781 463 vs 1389 Chinese >/=95 Mitochondrial Haplogroup 19641616
8020A,3010A,5178A,10400T mtDNA 0.549 463 vs 1389 Chinese >/=95 Mitochondrial Haplogroup 19641616
8964T,8020A,3010A,5178A,10400T mtDNA 0.319 463 vs 1389 Chinese >/=95 Mitochondrial Haplogroup 19641616
9296T,8964T,8020A,3010A,5178A,10400T mtDNA 0.55 463 vs 1389 Chinese >/=95 Mitochondrial Haplogroup 19641616
1107C,5178A,10400T mtDNA 0.559 463 vs 1389 Chinese >/=95 Mitochondrial Haplogroup 19641616
14569A,10400T mtDNA 0.796 463 vs 1389 Chinese >/=95 Mitochondrial Haplogroup 19641616
4833G,14569A,10400T mtDNA 0.949 463 vs 1389 Chinese >/=95 Mitochondrial Haplogroup 19641616
7600A,4833G,14569A,10400T mtDNA 0.153 463 vs 1389 Chinese >/=95 Mitochondrial Haplogroup 19641616
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  • 25 of 87 variants