Browse
Search
About
Home
Longevity DB
Genetic variants implicated in human longevity.
Browse
leave this field blank to prove your humanity
African European
Australian
Canadian
English People
Finn
Georgian
Human
Israeli
Multiethnic
Pomeranian
Sichuan
Spanish
Terraner
Age, Gene/Environment Susceptibility -Reykjavik Study Cohort (Island)
American
African American
American (Caucasian)
Amish
Atherosclerosis Risk Communities Study Cohort
Baltimore Longitudinal Study of Ageing Cohort
Cardiovascular Health Study Cohort
Caucasians (USA)
CHS (USA)
Framingham Heart Study Cohort
Framingham Heart Offspring Study Cohort
Gaucha population (Native South American)
Gerorgia (US)
New England American
North American
Mexican
Mexican Mestizo (see notes)
Study of Osteoporotic Fractures Cohort
The Health, Aging and Body Composition (USA)
US North European
USA (Black and European)
USA (Casucasians)
USA (Framington Heart Study)
Arab
Israelis
Nigerian
Tunisian
Turkish
Asian
Chinese
Bama Chinese
Chuang Chinese
Dujiangyan Han Chinese
Guangxi Bama Chinese
Han
Kahzak
Northern Chinese
Shanghai Chinese
Shenyang Chinese
Southern Chinese
Uyghur
Xinjiang Hetian Uyghur
Zhuang
Bama Zhuang
Japanese
Okinawan
Tokyo Japanese
Korean
Australian (Caucasian)
Australian centenarians of Caucasian ancestry
Brazilian
Gaucha Brazilian
Caucasian
Caucasian (NECS cohort)
Caucasian north
mostly Caucasian
European
African/European
British
English
Central European
Polish
Croatian
Danish
Dutch
Leiden Population
Rotterdam Population
Eastern European
European and Caucasian (many different european countries)
European Caucasian (Portuguese
European-origin (Caucasian)
French
German
Study of Health in Pomerania (Germany)
Greek
Irish
Belfast Irish
Northern Irish
Italian
Calabrian
Central Italian
Continental Italian
Invecchiare nel Chianti Cohort
Northeastern Italian
Northern Italian
Lombardy region Northern Italian
Northerncentral Italian
Sardinian
Southern Italian
Apulian
Calabrian
Northern European
Finns
Southern Finns
Tampere Population
Scottish
Southeastern Europe
Bulgarian
Southern European
Swiss
Western European
Spaniard
Caucasian Spanish
Caucasians from the city of Lleida in northeast Spain
Northern Spaniard
Spanish Combined: Pyrenees and Ebro’s Valley
Swedish
White European
Female
Caucasian Women
Georgia
Hispanic
Jewish
Ashkenazi Jewish
European-American Ashkenazi Jewish
Jordanian
Louisiana
Male
Mixed
Mixed Non-Hisp White
Slavs
Soviet
Russian
St. Petersburg Russian
Tatar
Tartarish
Population:
+
-
Canadian (1)
Finn (3)
Spanish (1)
American (1)
Chinese (11)
Japanese (2)
Brazilian (1)
Caucasian (3)
Danish (2)
Dutch (3)
Italian (23)
Spaniard (4)
Ashkenazi Jewish (1)
Study type:
+
-
Candidate Region/Gene «
Variant type:
+
-
Haplotype «
Variant effect:
+
-
Longevity‑Associated (31)
No Age Effect (17)
polymorphism
factor
odds ratio
pvalue
initial number
replication number
Population
age of cases
shorter lived allele
longer lived allele
study type
reference
e4
APOE
0.55
0.03
163 vs 1039
—
Spanish
100+
e4
—
Candidate Region/Gene
24534555
e4
APOE
0.41
0.05
79 vs 597
—
Italian
100+
e4
—
Candidate Region/Gene
24534555
e4
APOE
0.35
0.001
729 vs 498
—
Japanese
100+
e4
—
Candidate Region/Gene
24534555
e4
APOE
—
0.04
376 vs 376
—
Canadian
85+
e4
—
Candidate Region/Gene
24126160
apoE haplotypes
APOE
—
0.013
35 old vs 71 young vs 54 MI patients
—
Chinese
90+
apoE4
—
Candidate Region/Gene
11780357
LPA isoform
LPA
—
0.05
84 (cases) vs 517
—
Japanese
80+
Lp(a)F, Lp(a)B
—
Candidate Region/Gene
11269751
apoE haplotypes
APOE
—
0.013
35 old vs 71 young vs 54 MI patients
—
Chinese
90
apoE4
—
Candidate Region/Gene
11780357
rs1800591-rs61733139
MTTP
—
0.61
197 vs 251
—
Dutch
Mean age 93.8±3.1
—
—
Candidate Region/Gene
16611701
HP*1 F/S
HP
0.82
0.33
1072 total
—
Italian
>88
—
—
Candidate Region/Gene
21147083
rs2234693 - rs2234693
ESR1
—
0.12
108 vs 85
—
Italian
90+
—
—
Candidate Region/Gene
20819792
APOE polymorphism
APOE
—
0.437
1408 cases
—
Brazilian
69.3 +/- 7.2
—
—
Candidate Region/Gene
17934638
APOE polymorphism - HP1/2 common polymorphism
APOE
—
0.013
200 (cases) vs 539 (initial)
—
Italian
>88
e4-H2 (haplotype)
—
Candidate Region/Gene
21703254
HP1/2 common polymorphism
HP
—
0.05
200 (cases) vs 539 (initial) (initial)
—
Italian
>88
—
—
Candidate Region/Gene
21703254
Haplogroup J
—
0.38
0.025
98 vs 117
—
Chinese
90–100
—
—
Candidate Region/Gene
18759861
A-3826G (rs1800592) - C-3740A
UCP1
0.81
0.014
236 vs 741
—
Italian
>91
G-A
—
Candidate Region/Gene
21827845
rs3176343-rs3176344-rs3176349-rs1801270
CDKN1A
—
0.9852
184 vs 184
—
Italian
100
—
—
Candidate Region/Gene
20126416
rs3176343-rs3176344-rs3176349-rs1801270
CDKN1A
—
0.1761
184 vs 184
—
Italian
100
—
—
Candidate Region/Gene
20126416
rs3176343-rs3176344-rs3176349-rs1801270
CDKN1A
—
0.1282
184 vs 184
—
Italian
100
—
—
Candidate Region/Gene
20126416
rs3176343-rs3176344-rs3176349-rs1801270-rs1059234-rs876581
CDKN1A
—
0.8
184 vs 184
—
Italian
100
—
—
Candidate Region/Gene
20126416
rs3176343-rs3176344-rs3176349-rs1801270-rs1059234-rs876581
CDKN1A
—
0.1856
184 vs 184
—
Italian
100
—
—
Candidate Region/Gene
20126416
rs3176343-rs3176344-rs3176349-rs1801270-rs1059234-rs876581
CDKN1A
—
0.139
184 vs 184
—
Italian
100
—
—
Candidate Region/Gene
20126416
C4B1
C4B
—
0.05
77 (cases) vs 235
—
Italian
Mean age 101
—
—
Candidate Region/Gene
10219002
rs1800591-rs61733139
MTTP
—
0.93
164 vs 261
—
Dutch
Mean age 93.8 ± 3.1
—
—
Candidate Region/Gene
16611701
rs699947-(−1190G/A)-rs1570360-(−634G/C)
VEGFA
—
0.03
—
332 vs 648
Italian
85-99 (mean 89.8±2.8)
non A-A-G-G haplotypes
A-A-G-G
Candidate Region/Gene
17574707
rs1042718-rs1042719
ADRB2
0.63
1.86e-05
384 vs 384
579 vs 644
Chinese
Mean age 102.1±0.20
G-C
A-C
Candidate Region/Gene
23020224
Page 1 of 3
Next
25 of 53 variants
leave this field blank to prove your humanity