| polymorphism | factor | odds ratio | pvalue | initial number | replication number | Population | age of cases | shorter lived allele | longer lived allele | study type | reference |
| mtDNA haplotype | — | — | 0.0052 | 212 vs 275 | — | Italian | 100+ | non-J haplogroups | — | Mitochondrial Haplogroup | 10463944 |
| 55 (L/M) | PON1 | 0.94 | 0.44 | 308 vs 579 Italian, 296 vs 296 Irish | — | Irish, Italian | Italian 100.8 years, Irish 89.8 years | — | — | Candidate Region/Gene | 15050299 |
| 192 (Q/R) | PON1 | 1.30 | 0.007 | 308 vs 579 Italian, 296 vs 296 Irish | — | Irish, Italian | Italian 100.8 years, Irish 89.8 years | Q | — | Candidate Region/Gene | 15050299 |
| ?60H | LMP2 | — | 0.756 | 157 vs 311 | — | Italian | 88+ | H | — | Candidate Region/Gene | 11772516 |
| ?145K | LMP7 | — | 0.849 | 157 vs 311 | — | Italian | 88+ | K | — | Candidate Region/Gene | 11772516 |
| rs854560 | PON1 | — | 1.0 | 579 vs 308 | — | Italian | Over 100 | — | — | Candidate Region/Gene | 12082503 |
| codon 192 | PON1 | — | 1.0 | 192 vs 77 | — | Italian | 56 ages 66 to 89, 96 >90 | — | — | Candidate Region/Gene | 16799134 |
| codon 55 | PON1 | — | 1.0 | 192 vs 77 | — | Italian | 56 ages 66 to 89, 96 >90 | — | — | Candidate Region/Gene | 16799134 |
| Not specified | REN | — | 0.029 | 157 vs 218 | — | Italian | Centenarians | 11 | — | Candidate Region/Gene | 15105583 |
| Not specified | IL2 | — | 0.05 | 470 vs 120 | — | Italian, Bulgarian | Age range: 65-99 | — | — | Candidate Region/Gene | 21299522 |
| Not specified | IFNG | — | 0.05 | 707 vs 339 | — | Turkish, Polish, Italian, Bulgarian | Age range: 65-99 | — | — | Candidate Region/Gene | 21299522 |
| - | HRAS1 | — | 0.05 | see notes; stratified by population; total = 1321 cases versus 1140 controls | 1 (specifically for SIRT3 in a French population) | French, German, Italian | centenarians; see notes | — | — | - | 19367319 |
| - | SIRT3 | — | 0.145 | see notes; stratified by population; total = 1321 cases versus 1140 controls | — | French, German, Italian | centenarians; see notes | — | — | - | 19367319 |
| - | TH | — | 0.05 | see notes; stratified by population; total = 1321 cases versus 1140 controls | — | French, German, Italian | centenarians; see notes | — | — | - | 19367319 |
| - | INS | — | 0.05 | see notes; stratified by population; total = 1321 cases versus 1140 controls | — | French, German, Italian | centenarians; see notes | — | — | - | 19367319 |
| - | IGF2 | — | 0.05 | see notes; stratified by population; total = 1321 cases versus 1140 controls | — | French, German, Italian | centenarians; see notes | — | — | - | 19367319 |
| rs4073591 | — | — | 0.05 | see notes; stratified by population; total = 1321 cases versus 1140 controls | — | French, German, Italian | centenarians; see notes | — | — | - | 19367319 |
| rs4073590 | DEAF1 | — | 0.05 | see notes; stratified by population; total = 1321 cases versus 1140 controls | — | French, German, Italian | centenarians; see notes | — | — | - | 19367319 |
| rs11040489 | KRTAP5-6 | — | 0.05 | see notes; stratified by population; total = 1321 cases versus 1140 controls | — | French, German, Italian | centenarians; see notes | — | — | - | 19367319 |
| rs4930001 | — | — | 0.05 | see notes; stratified by population; total = 1321 cases versus 1140 controls | — | French, German, Italian | centenarians; see notes | — | — | - | 19367319 |
| rs800140 | TSPAN32 | — | 0.05 | see notes; stratified by population; total = 1321 cases versus 1140 controls | — | French, German, Italian | centenarians; see notes | — | — | - | 19367319 |
| rs16928120 | — | — | 0.05 | see notes; stratified by population; total = 1321 cases versus 1140 controls | — | French, German, Italian | centenarians; see notes | — | — | - | 19367319 |
| rs189037 | ATM | 1.85 | 0.028 | 128 vs 150 | — | Italian | — | — | — | - | 22960875 |
| VNTR (Variable Number of Tandem Repeats) | APOB | — | 0.003 | 143 vs 158 | — | Italian | mean age is 102 years | 35 or more tandem repeats | — | Candidate Region/Gene | 9050915 |
| - | TH | — | 0.045 | 202 vs 170 vs 82 | — | Italian | 100-105 (oldest of 3 age groups, see notes) | — | — | Candidate Region/Gene | 11053670 |
