polymorphism | factor | odds ratio | pvalue | initial number | replication number | Population | age of cases | shorter lived allele | longer lived allele | study type | reference |
- | TH | — | 0.045 | 202 vs 170 vs 82 | — | Italian | 100-105 (oldest of 3 age groups, see notes) | — | — | Candidate Region/Gene | 11053670 |
marker D4S1564 | — | — | 0.044 | 308 | — | European | min. age 98 for one sibling. 91+ males, 95+ females | — | — | Genome-Wide Association Study | 11526246 |
rs201058276 | F7 | 0.68 | 0.01 | 187 vs 201 | — | Danish | centenarians | R | — | Candidate Region/Gene | 11602206 |
323ins10 | F7 | 0.69 | 0.01 | 187 vs 201 | — | Danish | centenarians | 323P0 | — | Candidate Region/Gene | 11602206 |
3' 28-base pair variable number tandem repeat (HRAS1 3'VNTR) | HRAS | 1.13 | 0.002 | 234 vs 467 | — | Italian | centenarians | a3 allele (see notes) | — | Candidate Region/Gene | 11943467 |
APOA1-MspI-RFLP (−75) | APOA1 | — | 0.016 | 229 vs 571 | — | Calabrian | 81–109 (median 101) | A (=Absence) | — | Candidate Region/Gene | 12556235 |
(A/C)−110 | HSP70-1 | 0.40 | 0.005 | 120 vs 471 | — | Italian | 100 years and above | A | — | Candidate Region/Gene | 14501185 |
rs28969505 | YTHDF2 | 2.19 | 0.023 | 137 vs 412 | — | Italian | age 99–109,years, mean age 101 years; 26 men, 111 women | — | — | Candidate Region/Gene | 16799135 |
rs2764264 | FOXO3 | — | 0.0002 | 213 vs 402 | — | Japanese | minimum 95; mean 97.9 | T | — | Candidate Region/Gene | 18765803 |
rs13217795 | FOXO3 | — | 0.0006 | 213 vs 402 | — | Japanese | minimum 95; mean 97.9 | T | — | Candidate Region/Gene | 18765803 |
rs2802292 | FOXO3 | — | 0.0001 | 213 vs 402 | — | Japanese | minimum 95; mean 97.9 | T | — | Candidate Region/Gene | 18765803 |
rs4880 | SOD2 | 0.91 | 0.002 | 1650 | — | Danish | All danes born in 1905 (Danish 1905 cohort) | T | — | Candidate Region/Gene | 19428448 |
rs1050450 | GPX1 | 0.93 | 0.008 | 1613 | — | Danish | All danes born in 1905 (Danish 1905 cohort) | C | — | Candidate Region/Gene | 19428448 |
rs1935949 | FOXO3A | 1.46 | 0.019 | 299 vs 603;279 vs 797;383 vs 363 | — | Caucasian | 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 114 | T | — | Candidate Region/Gene | 19489743 |
rs2153960 | FOXO3A | 1.16 | 0.019 | 300 vs 603;279 vs 797;383 vs 363 | — | Caucasian | 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 115 | — | — | Candidate Region/Gene | 19489743 |
rs3778588 | FOXO3A | 1.22 | 0.023 | 301 vs 603;279 vs 797;383 vs 363 | — | Caucasian | 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 116 | — | — | Candidate Region/Gene | 19489743 |
rs4946935 | FOXO3A | 1.48 | 0.018 | 302 vs 603;279 vs 797;383 vs 363 | — | Caucasian | 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 117 | A | — | Candidate Region/Gene | 19489743 |
rs12153009 | GHR | 0.87 | 0.033 | 305 vs 603;279 vs 797;383 vs 363 | — | Caucasian | 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 120 | — | — | Candidate Region/Gene | 19489743 |
rs2940923 | GHR | 1.21 | 0.0013 | 306 vs 603;279 vs 797;383 vs 363 | — | Caucasian | 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 121 | — | — | Candidate Region/Gene | 19489743 |
rs2940935 | GHR | 1.24 | 0.0031 | 307 vs 603;279 vs 797;383 vs 363 | — | Caucasian | 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 122 | — | — | Candidate Region/Gene | 19489743 |
rs2272037 | IGF1R | 1.19 | 0.021 | 316 vs 603;279 vs 797;383 vs 363 | — | Caucasian | 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 131 | — | — | Candidate Region/Gene | 19489743 |
rs3758391 | SIRT1 | 1.45 | 0.026 | 246 vs 236 | — | Chinese | 71.2±7.1 years | T | — | Candidate Region/Gene | 20633545 |
rs4746720 | SIRT1 | 1.35 | 0.022 | 246 vs 236 | — | Chinese | 71.2±7.1 years | T | — | Candidate Region/Gene | 20633545 |
rs770087 | DUSP6 | 1.53 | 0.002 | 386 vs 410 | 541 vs 469 | German | 100 to 110, mean age = 101.3 | C | — | Candidate Region/Gene | 20800603 |
rs2301582 | NALP1 | 1.30 | 0.011 | 386 vs 410 | 541 vs 469 | German | 100 to 110, mean age = 101.3 | C | — | Candidate Region/Gene | 20800603 |