Denigma Buck Institute Health Extension

Browse
polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
rs3758391 SIRT1 1.45 0.026 246 vs 236 — Chinese 71.2±7.1 years T — Candidate Region/Gene 20633545
rs4746720 SIRT1 1.35 0.022 246 vs 236 — Chinese 71.2±7.1 years T — Candidate Region/Gene 20633545
1376G/T;1388G/A;95A/G;871G/A;1024C/T;1360C/T;392 G/T G6PD 6.30 0.013 173 total (see notes) — Chinese >80 — — Candidate Region/Gene 17077204
rs4646994 ACE — 0.05 4000 — Chinese Minimum age 65 DD — Candidate Region/Gene 22456784
4491A,3705G,10400T mtDNA — 0.027 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
5417A,10873T mtDNA — 0.018 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
12358G,5417A,10873T mtDNA — 0.058 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
rs2291727 ADCY6 — 0.003 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 — — Candidate Region/Gene 23020224
rs2266968 MAPK1 — 0.048 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 — — Candidate Region/Gene 23020224
HLA-C phenotype HLA-C 0.49 0.02 201 vs 211 — Chinese >93 Cw3, Cw6. Cw7 — Candidate Region/Gene 9147371
Haplogroup J — 0.38 0.025 98 vs 117 — Chinese 90–100 — — Candidate Region/Gene 18759861
rs3928306 MT-RNR2 0.49 0.027 98 vs 117 — Chinese 90–100 A — Candidate Region/Gene 18759861
rs28359172 MT-ND5 0.30 0.003 98 vs 117 — Chinese 90–100 G — Candidate Region/Gene 18759861
E4 APOE — 0.013 35 vs 125 — Chinese 90 years or over — — Candidate Region/Gene 11780357
apoE haplotypes APOE — 0.013 35 old vs 71 young vs 54 MI patients — Chinese 90 apoE4 — Candidate Region/Gene 11780357
APOE4 APOE — 0.013 35 vs 125 — Chinese 90 years or over High E4 frequency — Candidate Region/Gene 11780357
rs1042718 ADRB2 1.27 0.014 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 C A Candidate Region/Gene 23020224
rs1042718-rs1042719 ADRB2 0.63 1.86e-05 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 G-C A-C Candidate Region/Gene 23020224
rs1061581-rs1043618-rs2227956 — 4.51 0.016 191 vs 53 — Chinese >90 non A-G-C or non A-C-T haplotypes A-C-T Candidate Region/Gene 19840767
rs1061581-rs1043618-rs2227956 — 3.46 0.025 191 vs 53 — Chinese >90 non A-G-C or non A-C-T haplotypes A-G-C Candidate Region/Gene 19840767
HLA-A phenotype HLA-A 1.95 0.002 201 vs 211 — Chinese 22 centenarians + 179 nonagenarians (mean age 93 ±1.04) A9 A30 Candidate Region/Gene 9147371
apoE haplotypes APOE — 0.013 35 old vs 71 young vs 54 MI patients — Chinese 90 apoE4 ApT4 Candidate Region/Gene 11780357
rs4746720 — 1.35 0.022 246 vs 236 — Chinese 60-90 — C Candidate Region/Gene 20633545
rs4946936 FOXO3 1.40 1.8e-05 761 vs 1056 350 vs 350 Chinese mean age 102.3 T C Candidate Region/Gene 19793722
rs1042719 ADRB2 1.29 1.29 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 G C Candidate Region/Gene 23020224
  • Page 1 of 2
  • 25 of 40 variants