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| polymorphism | factor | odds ratio | pvalue | initial number | replication number | Population | age of cases | shorter lived allele | longer lived allele | study type | reference |
|---|---|---|---|---|---|---|---|---|---|---|---|
| - | Insulin signaling pathway (IIS) | — | 0.01 | 403 vs 1670 | — | European | 90-103 | — | — | Genome-Wide Association Study | 22113349 |
| - | Telomere maintenance pathway (TM) | — | 0.02 | 403 vs 1670 | — | European | 90-103 | — | — | Genome-Wide Association Study | 22113349 |
| 3p24-22 | 3p24-22 | — | 0.037 | 3953 | — | American | Minimum age 98 | — | — | Genome-Wide Association Study | 20824210 |
| GH1 "intron SNP" | GH1 | — | 0.019 | 866 | — | Dutch | Minimum age 85 | — | — | Candidate Region/Gene | 15771611 |
| VNTR in intron 5 (DeltaEF1 site) | SIRT3 | — | 8e-05 | 242 vs 703 | — | Italian | Median age 102 | 2b | — | Candidate Region/Gene | 15676284 |
| VNTR in intron 5 (GATA3 site) | SIRT3 | — | 0.025 | 242 vs 703 | — | Italian | Median age 102 | 2a | — | Candidate Region/Gene | 15676284 |
| Not specified | REN | — | 0.029 | 157 vs 218 | — | Italian | Centenarians | 11 | — | Candidate Region/Gene | 15105583 |
| Ile119Val | PCMT1 | — | 0.049 | 40 vs 40 | — | Ashkenazi Jewish | Mean age 87.2 | — | — | Candidate Region/Gene | 10496068 |
| TGFB1 haplotypes | TGFB1 | — | 0.05 | 297 vs 130 | — | Turkish, Bulgarian | Age range: 65-99 | codon 10 C/C, codon 25 G/G | — | Candidate Region/Gene | 21299522 |
| TGFB1 haplotypes | TGFB1 | — | 0.05 | 60 vs 40 | — | Bulgarian | Age range: 65-99 | codon 10 C/C, codon 25 G/G; −988 C/C, −800 G/G | — | Candidate Region/Gene | 21299522 |
| KIR2DS3 haplotypes | KIR2DS3 | — | 0.05 | 100 vs 100 | — | Irish | Age range: 65-99 | — | — | Candidate Region/Gene | 21299522 |
| 192 | PON1 | 1.26 | 0.007 | Italian: 308 vs 579; Northern Irish: 296 vs 296 | — | Irish | Italian: Mean age 100.8 +/- 2.1; Northern Irish: Mean age 89.8 +/- 5.7 | Q | — | Candidate Region/Gene | 15050299 |
| rs7896005 | SIRT1 | — | 0.0056 | 224 vs 293 | 170 vs 220 | Caucasian | Range: 90-103 | A | — | Candidate Region/Gene | 21972126 |
| APOE polymorphism | APOE | — | 0.02 | 80 vs 391 | — | Greek | >80 | epsilon4 | — | Candidate Region/Gene | 17234815 |
| rs11235972 | UCP3 | — | 0.029 | 908 (1905 Cohort) vs 708 (Study of Middle-Aged Danish Twins (MADT)) | — | Danish | 93 | A | — | Candidate Region/Gene | 22743239 |
| rs3781907 | UCP3 | — | 0.05 | 908 (1905 Cohort) vs 708 (Study of Middle-Aged Danish Twins (MADT)) | — | Danish | 93 | G | — | Candidate Region/Gene | 22743239 |
| DR7 | HLA-DRB1 | — | 0.01 | 325 centenarians versus 229 nonagenarian siblings | — | French | — | — | — | - | 9425225 |
| DR11 | HLA-DRB1 | — | 0.01 | 325 centenarians versus 229 nonagenarian siblings | — | French | — | — | — | - | 9425225 |
| DR13 | HLA-DRB1 | — | 0.01 | 325 centenarians versus 229 nonagenarian siblings | — | French | — | — | — | - | 9425225 |
| rs189037 | ATM | 1.85 | 0.028 | 128 vs 150 | — | Italian | — | — | — | - | 22960875 |
| F5 G1691A | F5 | — | 0.002 | 400 neonates (187 female and 312 male), 184 healthy adults (129 female and 55 male), and 432 long-lived individuals (343 women and 89 men). | — | Polish | >95 years versus 44 years | — | — | - | 20720309 |
| rs11188059 | CYP2C | — | 0.04 | 616 centenarians versus control group of 945 younger individuals | — | German | — | — | — | Candidate Region/Gene | 21798861 |
| VNTR (Variable Number of Tandem Repeats) | APOB | — | 0.003 | 143 vs 158 | — | Italian | mean age is 102 years | 35 or more tandem repeats | — | Candidate Region/Gene | 9050915 |
| apoAIV(360:His) | APOA4 | — | 0.005 | 119 (see notes) vs 264 | — | French | 74.29 ∓ 8.46 | ApoAIV-1_x000D_, by the order of the sentence - I'm assuming it's Glutamine = G | — | Candidate Region/Gene | 9533408 |
| HinfI347 | APOA4 | — | 0.05 | 71 vs 100 | — | Italian | mean102.3 years | — | — | Candidate Region/Gene | 9622284 |