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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
rs5882 CETP 0.63 Multiethnic Meta-Analysis 24468472
rs708272 CETP 0.53 Multiethnic Meta-Analysis 24468472
rs662 PON1 1.06 0.33 Irish >/=80 Candidate Region/Gene 20362697
rs662 PON1 1.06 0.11 Danish, Dutch, French, German, Italian, Tatar >/=80 Candidate Region/Gene 20362697
rs662 PON1 1.03 0.55 Irish >/=100 Candidate Region/Gene 20362697
rs4673 1.48 0.022 Russian C T Candidate Region/Gene 23755540
rs3814314 LMNA 0.017 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 Candidate Region/Gene 22340368
rs11578696 LMNA 0.21 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) Mean age 101.5 Candidate Region/Gene 22340368
rs4661146 LMNA 0.12 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 Candidate Region/Gene 22340368
rs1801133 MTHFR 0.029 (150 m, 74 f) vs (121 m, 320 f) Ashkenazi Jewish Mean age 75 C Candidate Region/Gene 15621215
rs4880 SOD2 0.009 (150 m, 74 f) vs (121 m, 320 f) Ashkenazi Jewish Mean age 75 T Candidate Region/Gene 15621215
rs769449 APOE 0.70 0.018 1,089 vs 736 1,613 vs 1,104 Danish, German 92-93 Danish, 95–110 German G 22234866
rs2069827 IL6 0.064 1,089 vs 736 563 (longtitudinal study) Danish, Dutch 92+ Danish, 85+ Dutch A 22234866
rs1042522 TP53 0.57 0.006 100 very old vs 280 old vs 189 young Italian 91+, 73-91 P Candidate Region/Gene 23125046
rs3772190 TERC 0.006 1013 total Danish A G Candidate Region/Gene 22136229
rs12696304 TERC 0.248 1013 total Danish Candidate Region/Gene 22136229
rs1800775 CETP 0.02 10261 Danish 20-93, followed for up to 34 years CC non-CC Candidate Region/Gene 23083790
rs708272 CETP 0.02 10261 Danish 20-93, followed for up to 34 years GG non-GG Candidate Region/Gene 23083790
rs2282679 GC 0.6 1038 vs 461 Dutch 59.5 years (offspring of nonagerians) Candidate Region/Gene 23128285
rs2107538 RANTES 3.20 0.029 104 vs 110 Spaniard Mean age 89.4 A G Candidate Region/Gene 22265023
rs2280789 RANTES 8.80 0.03 104 vs 110 Spaniard Mean age 89.5 C T Candidate Region/Gene 22265023
rs1937 TFAM 0.003 107 vs 284 Spaniard 100–111 G CC (genotype) Candidate Region/Gene 23186209
rs1801133 MTHFR 0.01 108 (patients with CVD) vs 118 Swiss >65 C Candidate Region/Gene 10583447
rs4646 CYP19 1.90 0.04 108 vs 85 Italian 90+ T Candidate Region/Gene 20819792
rs2234693 ESR1 0.08 108 vs 85 Italian 90+ PP (genotype) Candidate Region/Gene 20819792
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  • 25 of 572 variants