Denigma Buck Institute Health Extension

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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
rs4661146 LMNA — 0.12 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 — — Candidate Region/Gene 22340368
rs3814314 LMNA — 0.017 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 — — Candidate Region/Gene 22340368
APOE4 APOE — 0.71 106 vs 349 — American 70-79 (duration of study - 7 years) e4 — Candidate Region/Gene 16799145
rs3800358 BTBD9 — 0.00541 1173 vs 570 — American 85-100 — T Genome-Wide Association Study 22533364
rs1974676 Intergenic — 0.00496 1173 vs 570 — American 85-100 — G Genome-Wide Association Study 22533364
rs1834497 CLSTN2 — 0.00979 1173 vs 570 — American 85-100 — A Genome-Wide Association Study 22533364
rs2590504 KIAA0649 — 0.00854 1173 vs 570 — American 85-100 — C Genome-Wide Association Study 22533364
rs2024714 CDH4 — 7.43e-05 1173 vs 570 — American 85-100 — C Genome-Wide Association Study 22533364
rs41383 NLRC5 — 0.00455 1173 vs 570 — American 85-100 — C Genome-Wide Association Study 22533364
rs16975963 Noncoding — 0.00713 1173 vs 570 — American 85-100 — G Genome-Wide Association Study 22533364
rs13008689 Intergenic — 0.00686 1173 vs 570 — American 85-100 — A Genome-Wide Association Study 22533364
rs3120819 Intergenic — 0.00806 1173 vs 570 — American 85-100 — C Genome-Wide Association Study 22533364
rs9876781 Noncoding — 0.000868 1173 vs 570 — American 85-100 — A Genome-Wide Association Study 22533364
rs9517320 STK24 — 0.00204 1173 vs 570 — American 85-100 — C Genome-Wide Association Study 22533364
rs139170 PARVG — 0.00332 1173 vs 570 — American 85-100 — T Genome-Wide Association Study 22533364
rs4648884 RUNX3 — 0.00992 1173 vs 570 — American 85-100 — T Genome-Wide Association Study 22533364
rs739401 CARS — 0.00154 1173 vs 570 — American 85-100 — C Genome-Wide Association Study 22533364
rs10256972 C7orf50 — 0.00224 1173 vs 570 — American 85-100 — A Genome-Wide Association Study 22533364
rs10937739 PPP2R2C — 0.00404 1173 vs 570 — American 85-100 — T Genome-Wide Association Study 22533364
rs5771675 FAM19A5 — 0.00985 1173 vs 570 — American 85-100 — A Genome-Wide Association Study 22533364
rs12623542 Noncoding — 0.00192 1173 vs 570 — American 85-100 — G Genome-Wide Association Study 22533364
rs9616906 AC000050.2 — 9.36e-05 1173 vs 570 — American 85-100 — A Genome-Wide Association Study 22533364
rs13053175 RAC2 — 0.00697 1173 vs 570 — American 85-100 — T Genome-Wide Association Study 22533364
rs4148544 ABCC4 — 0.00977 1173 vs 570 — American 85-100 — T Genome-Wide Association Study 22533364
rs2370413 CACNA1C — 0.0011 1173 vs 570 — American 85-100 — T Genome-Wide Association Study 22533364
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  • 25 of 303 variants