polymorphism | factor | odds ratio | pvalue | initial number | replication number | Population | age of cases | shorter lived allele | longer lived allele | study type | reference |
rs699947-(−1190G/A)-rs1570360-(−634G/C) | VEGFA | — | 0.03 | — | 332 vs 648 | Italian | 85-99 (mean 89.8±2.8) | non A-A-G-G haplotypes | A-A-G-G | Candidate Region/Gene | 17574707 |
rs4673 | — | 1.48 | 0.022 | — | — | Russian | — | C | T | Candidate Region/Gene | 23755540 |
rs11578696 | LMNA | — | 0.21 | 873 vs 443 (initial) | New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) | | Mean age 101.5 | — | — | Candidate Region/Gene | 22340368 |
rs4661146 | LMNA | — | 0.12 | 873 vs 443 (initial) | New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) | American, Caucasian | Mean age 101.5 | — | — | Candidate Region/Gene | 22340368 |
rs3814314 | LMNA | — | 0.017 | 873 vs 443 (initial) | New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) | American, Caucasian | Mean age 101.5 | — | — | Candidate Region/Gene | 22340368 |
rs1801133 | MTHFR | — | 0.029 | (150 m, 74 f) vs (121 m, 320 f) | — | Ashkenazi Jewish | Mean age 75 | — | C | Candidate Region/Gene | 15621215 |
rs4880 | SOD2 | — | 0.009 | (150 m, 74 f) vs (121 m, 320 f) | — | Ashkenazi Jewish | Mean age 75 | — | T | Candidate Region/Gene | 15621215 |
A/G | IGF2 | — | 0.063 | (150 m, 74 f) vs (121 m, 320 f) | — | Ashkenazi Jewish | Mean age 75 | — | A, AA | Candidate Region/Gene | 15621215 |
rs429358, rs7412 | APOE | — | 0.025 | (150 m, 74 f) vs (121 m, 320 f) | — | Ashkenazi Jewish | Mean age 75 | e4 | e2 | Candidate Region/Gene | 15621215 |
- | F5 | — | 0.045 | (150 m, 74 f) vs (121 m, 320 f) | — | Ashkenazi Jewish | Mean age 75 | A | — | Candidate Region/Gene | 15621215 |
rs769449 | APOE | 0.70 | 0.018 | 1,089 vs 736 | 1,613 vs 1,104 | Danish, German | 92-93 Danish, 95–110 German | G | — | — | 22234866 |
rs1042522 | TP53 | 0.57 | 0.006 | 100 very old vs 280 old vs 189 young | — | Italian | 91+ (very old), 73-91 (old) | G | C | Candidate Region/Gene | 23125046 |
KIR2DS3 haplotypes | KIR2DS3 | — | 0.05 | 100 vs 100 | — | Irish | Age range: 65-99 | — | — | Candidate Region/Gene | 21299522 |
rs3772190 | TERC | — | 0.006 | 1013 total | — | Danish | — | A | G | Candidate Region/Gene | 22136229 |
rs1800775 | CETP | — | 0.02 | 10261 | — | Danish | 20-93, followed for up to 34 years | CC | non-CC | Candidate Region/Gene | 23083790 |
rs708272 | CETP | — | 0.02 | 10261 | — | Danish | 20-93, followed for up to 34 years | GG | non-GG | Candidate Region/Gene | 23083790 |
rs2060793 | CYP2R1 | — | 0.04 | 1038 (offspring of nonagenarians who had at least one nonagenarian sibling) vs 461 (offsprings' partners) | — | Dutch | Males: >/= 89; Females: >/= 91 | — | — | Candidate Region/Gene | 23128285 |
rs2107538 | RANTES | 3.20 | 0.029 | 104 vs 110 | — | Spaniard | Mean age 89.4 | A | G | Candidate Region/Gene | 22265023 |
rs2280789 | RANTES | 8.80 | 0.03 | 104 vs 110 | — | Spaniard | Mean age 89.5 | C | T | Candidate Region/Gene | 22265023 |
rs2107538-rs2280789 | RANTES | — | 0.04 | 104 vs 110 | — | Spaniard | Mean age 89.6 | non G-C haplotypes | G-C | Candidate Region/Gene | 22265023 |
rs2107538-rs2280789 | RANTES | 4.90 | 0.03 | 104 vs 110 | — | Spaniard | Mean age 89.6 | non A-T haplotypes | A-T | Candidate Region/Gene | 22265023 |
rs11568820-rs4516035-rs10735810-rs1544410-rs17878969 | VDR | 11.50 | 0.024 | 104 vs 114 | — | Caucasian, Spaniard | >85 | G-G-C-G-S | non G-G-C-G-S haplotypes | Candidate Region/Gene | 20407924 |
rs1544410-rs17878969 | VDR | 15.30 | 0.001 | 104 vs 114 | — | Caucasian, Spaniard | >85 | non G-S haplotypes | G-S | Candidate Region/Gene | 20407924 |
APOE4 | APOE | — | 0.71 | 106 vs 349 | — | American | 70-79 (duration of study - 7 years) | e4 | — | Candidate Region/Gene | 16799145 |
HP 1/2 | HP | 1.27 | 0.0194 | 1072 total | — | Italian | >88 | HP*2 | HP*1 | Candidate Region/Gene | 21147083 |