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Longevity DB
Genetic variants implicated in human longevity.
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African European
Australian
Canadian
English People
Finn
Georgian
Human
Israeli
Multiethnic
Pomeranian
Sichuan
Spanish
Terraner
Age, Gene/Environment Susceptibility -Reykjavik Study Cohort (Island)
American
African American
American (Caucasian)
Amish
Atherosclerosis Risk Communities Study Cohort
Baltimore Longitudinal Study of Ageing Cohort
Cardiovascular Health Study Cohort
Caucasians (USA)
CHS (USA)
Framingham Heart Study Cohort
Framingham Heart Offspring Study Cohort
Gaucha population (Native South American)
Gerorgia (US)
New England American
North American
Mexican
Mexican Mestizo (see notes)
Study of Osteoporotic Fractures Cohort
The Health, Aging and Body Composition (USA)
US North European
USA (Black and European)
USA (Casucasians)
USA (Framington Heart Study)
Arab
Israelis
Nigerian
Tunisian
Turkish
Asian
Chinese
Bama Chinese
Chuang Chinese
Dujiangyan Han Chinese
Guangxi Bama Chinese
Han
Kahzak
Northern Chinese
Shanghai Chinese
Shenyang Chinese
Southern Chinese
Uyghur
Xinjiang Hetian Uyghur
Zhuang
Bama Zhuang
Japanese
Okinawan
Tokyo Japanese
Korean
Australian (Caucasian)
Australian centenarians of Caucasian ancestry
Brazilian
Gaucha Brazilian
Caucasian
Caucasian (NECS cohort)
Caucasian north
mostly Caucasian
European
African/European
British
English
Central European
Polish
Croatian
Danish
Dutch
Leiden Population
Rotterdam Population
Eastern European
European and Caucasian (many different european countries)
European Caucasian (Portuguese
European-origin (Caucasian)
French
German
Study of Health in Pomerania (Germany)
Greek
Irish
Belfast Irish
Northern Irish
Italian
Calabrian
Central Italian
Continental Italian
Invecchiare nel Chianti Cohort
Northeastern Italian
Northern Italian
Lombardy region Northern Italian
Northerncentral Italian
Sardinian
Southern Italian
Apulian
Calabrian
Northern European
Finns
Southern Finns
Tampere Population
Scottish
Southeastern Europe
Bulgarian
Southern European
Swiss
Western European
Spaniard
Caucasian Spanish
Caucasians from the city of Lleida in northeast Spain
Northern Spaniard
Spanish Combined: Pyrenees and Ebro’s Valley
Swedish
White European
Female
Caucasian Women
Georgia
Hispanic
Jewish
Ashkenazi Jewish
European-American Ashkenazi Jewish
Jordanian
Louisiana
Male
Mixed
Mixed Non-Hisp White
Slavs
Soviet
Russian
St. Petersburg Russian
Tatar
Tartarish
Population:
+
-
Finn (8)
Georgian (4)
Multiethnic (5)
Sichuan (13)
American (33)
Turkish (1)
Chinese (60)
Japanese (49)
Korean (4)
Brazilian (1)
Caucasian (39)
European (1)
British (16)
Polish (7)
Danish (22)
Dutch (14)
French (18)
German (101)
Greek (3)
Irish (8)
Italian (161)
Calabrian (5)
Northern European (3)
Scottish (2)
Bulgarian (2)
Spaniard (1)
Ashkenazi Jewish (7)
Jordanian (5)
Tatar (1)
Study type:
+
-
‑ (19)
Candidate Region/Gene (382)
Meta‑Analysis (8)
Genome‑Wide Association Study (103)
Mitochondrial Haplogroup (27)
Variant type:
+
-
SNP (314)
Haplotype (43)
Other (1)
STR (7)
Deletion (1)
Variant effect:
+
-
No Age Effect «
polymorphism
factor
odds ratio
pvalue
initial number
replication number
Population
age of cases
shorter lived allele
longer lived allele
study type
reference
rs939915
SIRT3
—
0.0145
2461 samples (cases and controls combined)
—
Italian
—
—
—
Candidate Region/Gene
19367319
rs1528753
—
—
8.1e-08
1345 cohort + 1087 offspring
—
American
—
—
—
Genome-Wide Association Study
17903295
rs2371208
—
—
2.6e-06
1345 cohort + 1087 offspring
—
American
—
—
—
Genome-Wide Association Study
17903295
rs10496799
NXPH2
—
1.4e-05
1345 cohort + 1087 offspring
—
American
—
—
—
Genome-Wide Association Study
17903295
rs10489006
—
—
3.6e-05
1345 cohort + 1087 offspring
—
American
—
—
—
Genome-Wide Association Study
17903295
rs3757354
MYLIP
—
6.4e-05
1345 cohort + 1087 offspring
—
American
—
—
—
Genome-Wide Association Study
17903295
rs10493513
—
—
1.5e-06
1345 cohort + 1087 offspring
—
American
—
—
—
Genome-Wide Association Study
17903295
rs10493514
—
—
2.8e-06
1345 cohort + 1087 offspring
—
American
—
—
—
Genome-Wide Association Study
17903295
rs6689491
—
—
2e-05
1345 cohort + 1087 offspring
—
American
—
—
—
Genome-Wide Association Study
17903295
rs10493515
—
—
2.3e-05
1345 cohort + 1087 offspring
—
American
—
—
—
Genome-Wide Association Study
17903295
rs10493518
—
—
3.6e-05
1345 cohort + 1087 offspring
—
American
—
—
—
Genome-Wide Association Study
17903295
rs10493517
—
—
4.2e-05
1345 cohort + 1087 offspring
—
American
—
—
—
Genome-Wide Association Study
17903295
rs6657082
—
—
5.5e-05
1345 cohort + 1087 offspring
—
American
—
—
—
Genome-Wide Association Study
17903295
rs10498263
OR4Q3
—
8.3e-05
1345 cohort + 1087 offspring
—
American
—
—
—
Genome-Wide Association Study
17903295
rs1915501
—
—
0.00011
1345 cohort + 1087 offspring
—
American
—
—
—
Genome-Wide Association Study
17903295
rs1405051
—
—
0.00014
1345 cohort + 1087 offspring
—
American
—
—
—
Genome-Wide Association Study
17903295
rs6459623
IBRDC2
—
0.00015
1345 cohort + 1087 offspring
—
American
—
—
—
Genome-Wide Association Study
17903295
rs5882
CETP
—
0.63
—
—
Multiethnic
—
—
—
Meta-Analysis
24468472
rs708272
CETP
—
0.53
—
—
Multiethnic
—
—
—
Meta-Analysis
24468472
MTP -493G/T
MTP
—
0.854
—
—
Chinese
—
—
—
-
23273182
rs1078892
FOXO1
0.96
0.589
1447 vs 1029 (German)
166 vs 216 (Italian)
German
—
—
—
Candidate Region/Gene
21388494
rs2721044
FOXO1
0.90
0.097
1447 vs 1029 (German)
166 vs 216 (Italian)
German
—
—
—
Candidate Region/Gene
21388494
rs12865518
FOXO1
1.07
0.307
1447 vs 1029 (German)
166 vs 216 (Italian)
German
—
—
—
Candidate Region/Gene
21388494
rs17446593
FOXO1
0.93
0.338
1447 vs 1029 (German)
166 vs 216 (Italian)
German
—
—
—
Candidate Region/Gene
21388494
rs12696304
TERC
—
0.248
1013 total
—
Danish
—
—
—
Candidate Region/Gene
22136229
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