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Longevity DB
Genetic variants implicated in human longevity.
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African European
Australian
Canadian
English People
Finn
Georgian
Human
Israeli
Multiethnic
Pomeranian
Sichuan
Spanish
Terraner
Age, Gene/Environment Susceptibility -Reykjavik Study Cohort (Island)
American
African American
American (Caucasian)
Amish
Atherosclerosis Risk Communities Study Cohort
Baltimore Longitudinal Study of Ageing Cohort
Cardiovascular Health Study Cohort
Caucasians (USA)
CHS (USA)
Framingham Heart Study Cohort
Framingham Heart Offspring Study Cohort
Gaucha population (Native South American)
Gerorgia (US)
New England American
North American
Mexican
Mexican Mestizo (see notes)
Study of Osteoporotic Fractures Cohort
The Health, Aging and Body Composition (USA)
US North European
USA (Black and European)
USA (Casucasians)
USA (Framington Heart Study)
Arab
Israelis
Nigerian
Tunisian
Turkish
Asian
Chinese
Bama Chinese
Chuang Chinese
Dujiangyan Han Chinese
Guangxi Bama Chinese
Han
Kahzak
Northern Chinese
Shanghai Chinese
Shenyang Chinese
Southern Chinese
Uyghur
Xinjiang Hetian Uyghur
Zhuang
Bama Zhuang
Japanese
Okinawan
Tokyo Japanese
Korean
Australian (Caucasian)
Australian centenarians of Caucasian ancestry
Brazilian
Gaucha Brazilian
Caucasian
Caucasian (NECS cohort)
Caucasian north
mostly Caucasian
European
African/European
British
English
Central European
Polish
Croatian
Danish
Dutch
Leiden Population
Rotterdam Population
Eastern European
European and Caucasian (many different european countries)
European Caucasian (Portuguese
European-origin (Caucasian)
French
German
Study of Health in Pomerania (Germany)
Greek
Irish
Belfast Irish
Northern Irish
Italian
Calabrian
Central Italian
Continental Italian
Invecchiare nel Chianti Cohort
Northeastern Italian
Northern Italian
Lombardy region Northern Italian
Northerncentral Italian
Sardinian
Southern Italian
Apulian
Calabrian
Northern European
Finns
Southern Finns
Tampere Population
Scottish
Southeastern Europe
Bulgarian
Southern European
Swiss
Western European
Spaniard
Caucasian Spanish
Caucasians from the city of Lleida in northeast Spain
Northern Spaniard
Spanish Combined: Pyrenees and Ebro’s Valley
Swedish
White European
Female
Caucasian Women
Georgia
Hispanic
Jewish
Ashkenazi Jewish
European-American Ashkenazi Jewish
Jordanian
Louisiana
Male
Mixed
Mixed Non-Hisp White
Slavs
Soviet
Russian
St. Petersburg Russian
Tatar
Tartarish
Population:
+
-
German «
Danish (9)
Dutch (1)
French (2)
Italian (7)
Tatar (1)
Study type:
+
-
Candidate Region/Gene «
Variant type:
+
-
SNP (85)
CNV (1)
Variant effect:
+
-
Longevity‑Associated (27)
No Age Effect (73)
polymorphism
factor
odds ratio
pvalue
initial number
replication number
Population
age of cases
shorter lived allele
longer lived allele
study type
reference
56 SNPs - CYP2C gene family
CYP2C gene family: CYP2C8, CYP2C9, CYP2C18, CYP2C19
—
1.0
1,384 vs 945
—
German
Mean age 98.8
—
—
Candidate Region/Gene
21798861
rs3758391
SIRT1
—
1.0
386 vs 640 vs 547
—
German
Mean age 101
—
—
Candidate Region/Gene
16257164
rs1885472
SIRT1
—
1.0
386 vs 640 vs 547
—
German
Mean age 101
—
—
Candidate Region/Gene
16257164
rs2273773
SIRT1
—
1.0
386 vs 640 vs 547
—
German
Mean age 101
—
—
Candidate Region/Gene
16257164
rs10997870
SIRT1
—
1.0
386 vs 640 vs 547
—
German
Mean age 101
—
—
Candidate Region/Gene
16257164
rs2234975
SIRT1
—
1.0
386 vs 640 vs 547
—
German
Mean age 101
—
—
Candidate Region/Gene
16257164
rs1801274
FCGR2A
—
1.0
408 vs 446 vs 454
—
German
Centenarians
—
—
Candidate Region/Gene
16893392
length (STR polymorphism)
TH
—
1.0
196 vs 358
471 vs 462
German
(in replication) 96-110 years
—
—
Candidate Region/Gene
21407269
rs1041740
SOD1
—
0.998
1612 vs 1104
—
German
90+
—
—
Candidate Region/Gene
24163049
rs12876443
FOXO1
1.00
0.989
1447 vs 1029 (German)
166 vs 216 (Italian)
German
Mean age 98.8
—
—
Candidate Region/Gene
21388494
rs5981072
FOXO4
0.98
0.976
1447 vs 1029 (German)
166 vs 216 (Italian)
German
Mean age 98.8
—
—
Candidate Region/Gene
21388494
rs8192287
SOD3
—
0.955
1612 vs 1104
—
German
90+
—
—
Candidate Region/Gene
24163049
rs2536512
SOD3
—
0.942
1612 vs 1104
—
German
90+
—
—
Candidate Region/Gene
24163049
rs1571631
FOXO3
0.99
0.872
388 vs 371
535 vs 553
German
mean age 98.4 years
—
—
Candidate Region/Gene
19196970
rs6690527
FOXO6
1.01
0.867
1447 vs 1029 (German)
166 vs 216 (Italian)
German
Mean age 98.8
—
—
Candidate Region/Gene
21388494
rs7855
SOD2
—
0.842
1612 vs 1104
—
German
90+
—
—
Candidate Region/Gene
24163049
rs1317557
FOXO6
1.04
0.824
1447 vs 1029 (German)
166 vs 216 (Italian)
German
Mean age 98.8
—
—
Candidate Region/Gene
21388494
rs6693260
FOXO6
0.98
0.824
1447 vs 1029 (German)
166 vs 216 (Italian)
German
Mean age 98.8
—
—
Candidate Region/Gene
21388494
rs2498796
AKT1
0.99
0.788
2996 vs 1840
—
Danish
,
German
92-110
—
—
Candidate Region/Gene
22929028
rs3803304
AKT1
0.99
0.784
2702 vs 1840
—
Danish
,
German
92-110
—
—
Candidate Region/Gene
22929028
rs9603776
FOXO1
1.05
0.778
1447 vs 1029 (German)
166 vs 216 (Italian)
German
Mean age 98.8
—
—
Candidate Region/Gene
21388494
rs2701893
FOXO1
0.98
0.772
1447 vs 1029 (German)
166 vs 216 (Italian)
German
Mean age 98.8
—
—
Candidate Region/Gene
21388494
rs2755209
FOXO1
0.98
0.77
1447 vs 1029 (German)
166 vs 216 (Italian)
German
Mean age 98.8
—
—
Candidate Region/Gene
21388494
rs2070424
SOD1
—
0.77
1612 vs 1104
—
German
90+
—
—
Candidate Region/Gene
24163049
rs13306703
—
—
0.764
1612 vs 1104
—
German
90+
—
—
Candidate Region/Gene
24163049
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25 of 102 variants
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