Denigma Buck Institute Health Extension

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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
rs7843014 PTK2 — 1.0 742 vs 499 — Japanese 100-116 — — Candidate Region/Gene 24930376
rs7460 PTK2 — 1.0 742 vs 499 — Japanese 100-116 — — Candidate Region/Gene 24930376
rs8051232 COQ7 — 0.9 213 vs 402 — Japanese minimum 95; mean 97.9 — — Candidate Region/Gene 18765803
rs2249466 CBL — 0.9 207 vs 394 — Japanese 95+ — — Candidate Region/Gene 23770741
rs1048310 — — 0.87 208 vs 399 — Japanese 95+ — — Candidate Region/Gene 23770741
rs7069102 SIRT1 — 0.84 213 vs 402 — Japanese minimum 95; mean 97.9 — — Candidate Region/Gene 18765803
rs361072 PIK3CB — 0.829 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
rs11217184 CBL — 0.8 212 vs 396 — Japanese 95+ — — Candidate Region/Gene 23770741
rs1801123 IRS1 — 0.774 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
rs2755213 FOXO1 — 0.77 213 vs 402 — Japanese minimum 95; mean 97.9 — — Candidate Region/Gene 18765803
rs7192898 COQ7 — 0.73 213 vs 402 — Japanese minimum 95; mean 97.9 — — Candidate Region/Gene 18765803
rs1885472 SIRT1 — 0.71 213 vs 402 — Japanese minimum 95; mean 97.9 — — Candidate Region/Gene 18765803
rs7914 CBL — 0.69 190 vs 376 — Japanese 95+ — — Candidate Region/Gene 23770741
rs3753645 SHC1 1.28 0.64 230 vs 180 — Japanese Mean age 100.8 +/- 1.5 T — Candidate Region/Gene 14530863
rs3753644 SHC1 1.28 0.64 230 vs 180 — Japanese Mean age 100.8 +/- 1.5 T — Candidate Region/Gene 14530863
rs2721069 FOXO1 — 0.62 213 vs 402 — Japanese minimum 95; mean 97.9 — — Candidate Region/Gene 18765803
rs1333049 CDKN2B-AS1 — 0.602 742 vs 920 — Japanese 100 — — Candidate Region/Gene 24163049
rs738288 ATF4 — 0.54 205 vs 396 — Japanese 95+ — — Candidate Region/Gene 23770741
rs1853432 JUN — 0.52 213 vs 398 — Japanese 95+ — — Candidate Region/Gene 23770741
rs2297626 FOXO1A — 0.512 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
rs3736265 PPARGC1A — 0.509 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
rs2297627 FOXO1A — 0.495 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
rs2755209 FOXO1 — 0.48 213 vs 402 — Japanese minimum 95; mean 97.9 — — Candidate Region/Gene 18765803
rs8192678 PPARGC1A — 0.469 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
rs3745544 INSR — 0.441 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
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  • 25 of 49 variants