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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
rs11136000 CLU 0.975 1364 American, British Age range 50-108; mean age at death 80.2 A G Candidate Region/Gene 22445811
rs744373 BIN1 0.689 1364 American, British Age range 50-108; mean age at death 80.2 A G Candidate Region/Gene 22445811
rs1485780 CD2AP 0.604 1364 American, British Age range 50-108; mean age at death 80.2 C A Candidate Region/Gene 22445811
rs3818361 CR1 0.563 1364 American, British Age range 50-108; mean age at death 80.2 G A Candidate Region/Gene 22445811
rs2275075 LMNA 0.54 873 vs 443 New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 American, Caucasian Mean age 101.5 Candidate Region/Gene 22340368
rs3865444 CD33 0.442 1364 American, British Age range 50-108; mean age at death 80.2 C A Candidate Region/Gene 22445811
rs11767557 EPHA1 0.267 1364 American, British Age range 50-108; mean age at death 80.2 G A Candidate Region/Gene 22445811
rs3851179 PICALM 0.227 1364 American, British Age range 50-108; mean age at death 80.2 G A Candidate Region/Gene 22445811
rs610932 MS4A6A 0.176 1364 American, British Age range 50-108; mean age at death 80.2 C A Candidate Region/Gene 22445811
rs3764650 ABCA7 0.135 1364 American, British Age range 50-108; mean age at death 80.2 C A Candidate Region/Gene 22445811
HRAS1 LASS1 (CCT) APOE 0.0511 68 vs 68 American Candidate Region/Gene 20569235
−438 G/A TAFI 0.53 0.003 2224 American, Caucasian 65+ G (men) Candidate Region/Gene 15939070
HRAS1 LASS1 (CCT) APOE 0.00197 125 vs 163 American Candidate Region/Gene 20569235
rs6459623 IBRDC2 0.00015 1345 cohort + 1087 offspring American Genome-Wide Association Study 17903295
rs1405051 0.00014 1345 cohort + 1087 offspring American Genome-Wide Association Study 17903295
rs1915501 0.00011 1345 cohort + 1087 offspring American Genome-Wide Association Study 17903295
HRAS1 LASS1 (CCT) APOE 9.5e-05 204 vs 251 American Candidate Region/Gene 20569235
rs10498263 OR4Q3 8.3e-05 1345 cohort + 1087 offspring American Genome-Wide Association Study 17903295
rs3757354 MYLIP 6.4e-05 1345 cohort + 1087 offspring American Genome-Wide Association Study 17903295
rs6657082 5.5e-05 1345 cohort + 1087 offspring American Genome-Wide Association Study 17903295
rs10493517 4.2e-05 1345 cohort + 1087 offspring American Genome-Wide Association Study 17903295
rs10489006 3.6e-05 1345 cohort + 1087 offspring American Genome-Wide Association Study 17903295
rs10493518 3.6e-05 1345 cohort + 1087 offspring American Genome-Wide Association Study 17903295
rs10493515 2.3e-05 1345 cohort + 1087 offspring American Genome-Wide Association Study 17903295
rs6689491 2e-05 1345 cohort + 1087 offspring American Genome-Wide Association Study 17903295
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  • 25 of 33 variants