Denigma Buck Institute Health Extension

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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
AAT M/Z/S AAT 0.18 1e-07 143 vs 255 vs 127 — Italian Centenarians M, S Z Candidate Region/Gene 17048073
G477T SIRT3 — 0.0272 801 — Italian 120 subject aged 100 or older GT TT Candidate Region/Gene 14580859
rs2069762 IL-2 1.43 0.096 168 vs 214 — Italian Centenarians G T Candidate Region/Gene 16518704
rs4646 CYP19 1.90 0.04 108 vs 85 — Italian 90+ — T Candidate Region/Gene 20819792
rs11555236 SIRT3 — 0.03 357 — Italian 70+ — T Candidate Region/Gene 23839864
rs6166 FSHR 4.21 0.036 114 vs 173 — Italian >/=90 Asn Ser Candidate Region/Gene 22985084
REN polymorphism - mtDNA mtDNA 3.27 0.006 157 — Italian 100+ — REN10 - mtDNA haplogroup H Candidate Region/Gene 11938442
192/55 loci PON1 — 0.01 579 vs 308 — Italian Over 100 — R+M+ Candidate Region/Gene 12082503
rs1801282 PPARG 0.13 0.03 114 vs 173 — Italian >/=90 Pro/Ala Pro/Pro, Ala/Ala Candidate Region/Gene 22985084
CHIT1 24-bp duplication CHIT1 — 0.05 129 vs 129 29 versus 129 Tunisian, Greek, Italian Mean age 97.6 Absence of duplication Presence of duplication Candidate Region/Gene 19881466
APOA1-MspI-RFLP A/P alleles APOA1 — 0.045 413 vs. 571 — Italian median age 101 A P Candidate Region/Gene 12556235
rs429358, rs7412 APOE — 0.009 1477 total — Italian 18-109 e4 non-e4 - 16896546
ADA genotypes ADA — 0.003 62 vs 64 vs143 vs 272 — Italian Minimum age 90 ADA*2 non-ADA*2 Candidate Region/Gene 20174870
HRAS1 3'VNTR HRAS 1.13 0.551 234 vs 467 — Italian Minimum age 100 a3 non-a3 Candidate Region/Gene 11943467
rs3176343-rs3176344-rs3176349-rs1801270-rs1059234-rs876581 CDKN1A — 0.02249 184 vs 184 — Italian 100 A-G-G-A-T-A non A-G-G-A-T-A haplotypes Candidate Region/Gene 20126416
rs3176343-rs3176344-rs3176349-rs1801270 CDKN1A — 0.03972 184 vs 184 — Italian 100 A-G-G-A non A-G-G-A haplotypes Candidate Region/Gene 20126416
HP 1/2 HP 1.27 0.0194 1072 total — Italian >88 HP*2 HP*1 Candidate Region/Gene 21147083
GSTT1 deletion GSTT1 — 0.03 94 vs 418 — Italian Mean age 100.2 Not homozygous for d Homozygous for delet Candidate Region/Gene 11162685
rs1800896 - rs1800629 IL10 — 0.038 174 vs 224 — Italian >100 — GG-GG (only in men) Candidate Region/Gene 12676903
rs1800896 IL10 — 0.019 174 vs 227 — Italian >100 — GG Candidate Region/Gene 12676903
rs1800896 IL-10 3.00 0.0003 142 vs 153 — Italian Mean age 67 AA GG Candidate Region/Gene 15466015
rs3176343-rs3176344-rs3176349-rs1801270-rs1059234-rs876581 CDKN1A — 0.00211 184 vs 184 — Italian 100 non G-G-G-C-C-G haplotypes G-G-G-C-C-G Candidate Region/Gene 20126416
rs3176343-rs3176344-rs3176349-rs1801270 CDKN1A — 0.00394 184 vs 184 — Italian 100 non G-G-G-C haplotypes G-G-G-C Candidate Region/Gene 20126416
rs1800629 TNF — 0.019 747 — Italian 19-110 A G Candidate Region/Gene 18511747
−1082 G/A IL10 — 0.025 190 vs 260 — Italian >99 years old — G Candidate Region/Gene 11857058
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