Denigma Buck Institute Health Extension

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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
rs7896005 SIRT1 — 0.0056 224 vs 293 170 vs 220 Caucasian Range: 90-103 A — Candidate Region/Gene 21972126
rs1042522 TP53 0.88 0.005 9219 participants (Copenhagen City Heart Study) — Danish Range: 20-95 G — Candidate Region/Gene 18256523
rs429358, rs7412 APOE — 0.0212 60 vs 89 — African European Range: 20-59 — — Candidate Region/Gene 20569235
K153R MSTN 3.48 0.001 156 vs 384 79 vs 316 (unelated Italian cohort) Spaniard Range : 100-111 K R Candidate Region/Gene 23354683
Arg 213 ->His SULT1A1 — 0.017 Total 165 — Nigerian, Caucasian range 17- 90 SULT1A1*2 — — 9854023
192/55 loci PON1 — 0.01 579 vs 308 — Italian Over 100 — R+M+ Candidate Region/Gene 12082503
Chromosome 4 at D4S1564 Chromosome 4 at D4S1564 — 0.044 303 — Human Minimum age 98 for one sibling (of sibship) — — Genome-Wide Association Study 11526246
3p24-22 3p24-22 — 0.037 3953 — American Minimum age 98 — — Genome-Wide Association Study 20824210
G1691A F5 — 0.004 432 vs 184 — Polish Minimum age 95 A G Candidate Region/Gene 20720309
rs5882 CETP — 0.05 300 vs 320 vs 258 — Ashkenazi Jewish Minimum age 95 AA, AG GG Candidate Region/Gene 15621216
ADA genotypes ADA — 0.003 62 vs 64 vs143 vs 272 — Italian Minimum age 90 ADA*2 non-ADA*2 Candidate Region/Gene 20174870
GH1 "intron SNP" GH1 — 0.019 866 — Dutch Minimum age 85 — — Candidate Region/Gene 15771611
mtDNA haplogroups mtDNA — 0.027 138 — Spaniard Minimum age 85 non-J J Mitochondrial Haplogroup 18931934
ACE D/I ACE — 0.02 689 — Danish Minimum age 73 II DI, DD Candidate Region/Gene 12547486
rs4646994 ACE — 0.05 4000 — Chinese Minimum age 65 DD — Candidate Region/Gene 22456784
D4a mtDNA haplogroups — 0.05 112 vs 96 — Japanese Minimum age 105 non-D4a D4a Complete Mitochondrial Genome 18545700
APOE e2/e3/e4 APOE 4.40 0.02 179 — Finn Minimum age 104 e3, e4 e2 Candidate Region/Gene 11213279
HRAS1 3'VNTR HRAS 1.13 0.551 234 vs 467 — Italian Minimum age 100 a3 non-a3 Candidate Region/Gene 11943467
rs2764264 FOXO3 — 0.0002 213 vs 402 — Japanese minimum 95; mean 97.9 T — Candidate Region/Gene 18765803
rs13217795 FOXO3 — 0.0006 213 vs 402 — Japanese minimum 95; mean 97.9 T — Candidate Region/Gene 18765803
rs2802292 FOXO3 — 0.0001 213 vs 402 — Japanese minimum 95; mean 97.9 T — Candidate Region/Gene 18765803
marker D4S1564 — — 0.044 308 — European min. age 98 for one sibling. 91+ males, 95+ females — — Genome-Wide Association Study 11526246
rs2866164 MTTP — 0.05 126 vs 288 — Ashkenazi Jewish median age = 97 CG/GG — Candidate Region/Gene 22496539
rs1800795 IL-6 — 0.007 323 (cases) vs 377 (initial) — Italian median age = 101 G C Candidate Region/Gene 11500818
rs10149689 TSHR 1.56 0.001 232 vs 163 — Ashkenazi Jewish Median age 97 A G Candidate Region/Gene 19837933
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  • 25 of 1027 variants