Denigma Buck Institute Health Extension

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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
rs4746720 SIRT1 1.35 0.022 246 vs 236 — Chinese 71.2±7.1 years T — Candidate Region/Gene 20633545
9 mtDNA haplogroups mtDNA haplogroup 0.38 0.025 98 vs. 117 — Chinese 90-100 years old J non-J - 18759861
Haplogroup J — 0.38 0.025 98 vs 117 — Chinese 90–100 — — Candidate Region/Gene 18759861
rs1061581-rs1043618-rs2227956 — 3.46 0.025 191 vs 53 — Chinese >90 non A-G-C or non A-C-T haplotypes A-G-C Candidate Region/Gene 19840767
rs3758391 SIRT1 1.45 0.026 246 vs 236 — Chinese 71.2±7.1 years T — Candidate Region/Gene 20633545
rs3758391 SIRT1 1.45 0.026 246 vs 236 — Chinese 60-90 — C Candidate Region/Gene 20633545
4491A,3705G,10400T mtDNA — 0.027 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
rs3928306 MT-RNR2 0.49 0.027 98 vs 117 — Chinese 90–100 A — Candidate Region/Gene 18759861
XbaI APOB 1.30 0.03 191 (case) vs 53 — Chinese > 90 baseline, Mean age 97 +/- 3 — X+X+ Candidate Region/Gene 17393087
rs429358 + rs7412 APOE — 0.04 1236 vs 326 — Chinese 60+ e4 non-e4 Candidate Region/Gene 9792194
rs2266968 MAPK1 — 0.048 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 — — Candidate Region/Gene 23020224
rs4646994 ACE — 0.05 4000 — Chinese Minimum age 65 DD — Candidate Region/Gene 22456784
rs1061581 HSPA1B — 0.05 191 vs 53 — Chinese >90 A G Candidate Region/Gene 19840767
12358G,5417A,10873T mtDNA — 0.058 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
rs1042719 ADRB2 1.29 1.29 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 G C Candidate Region/Gene 23020224