Longevity Variant Database

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    Populations | Study Types | Variant Types



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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    ASP299GLY TLR4 0.04 8 vs 8 Italian 25-50 16803999
    rs884949 ADARB2 1.19 0.0911 877 vs 1808 Southern Italian, age 90–109 (median 96): 459 vs 429. Ashkenazi Jewish, age 95–112 (median 100): 299 vs 269. Japanese, age 100-116 (median 106): 470 vs 538. Northern European 96–119 (median: 103) AA 20011587
    rs2805533 ADARB2 0.91 0.1904 877 vs 1808 Southern Italian, age 90–109 (median 96): 459 vs 429. Ashkenazi Jewish, age 95–112 (median 100): 299 vs 269. Japanese, age 100-116 (median 106): 470 vs 538. Northern European 96–119 (median: 103) AA/AG 20011587
    rs2387653 ADARB2 1.17 0.1053 877 vs 1808 Southern Italian, age 90–109 (median 96): 459 vs 429. Ashkenazi Jewish, age 95–112 (median 100): 299 vs 269. Japanese, age 100-116 (median 106): 470 vs 538. Northern European 96–119 (median: 103) AA 20011587
    GSTT1 gene deletion GSTT1 0.001 447 Danish 77.4 no deletion deletion - 16574194
    - HRAS1 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls 1 (specifically for SIRT3 in a French population) French, German, Italian centenarians; see notes - 19367319
    - SIRT3 0.145 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
    - TH 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
    - INS 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
    - IGF2 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
    rs4073591 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
    rs4073590 DEAF1 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
    rs11040489 KRTAP5-6 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
    rs4930001 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
    rs800140 TSPAN32 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
    rs16928120 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
    MTP -493G/T MTP 0.854 Chinese - 23273182
    - GSTM1 0.74 94 vs 418 Italian 100 years vs 46 years - 11162685
    rs4646903 CYP1A1 1.03 0.23 205 vs 294 German 80-89; reference group: 17-79 - 15177664
    rs1056836 CYP1B1 0.63 0.78 205 vs 294 German 80-89; reference group: 17-79 - 15177664
    rs1799814 CYP1A1 1.16 1.0 205 vs 294 German 80-89; reference group: 17-79 - 15177664
    R353Q FVII 0.61 113 vs 100 Scottish 96 years vs 32 years - 10744171
    IVS7 FVII 0.69 113 vs 100 Scottish 96 vs 32 - 10744171
    rs1800629 TNF 1.0 119 vs 118 Jordanian Mean age 90.2 Candidate Region/Gene 20518833
    rs708272 CETP 1.0 12 vs 190 vs 105 Greek 99-111 Candidate Region/Gene 23389097
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    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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