Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (1027)   No Age Effect (543)  
  • Study type: + -
    GWAS (2)   ‑ (27)   Candidate Region/Gene (784)   Meta‑Analysis (38)   Complete Mitochondrial Genome (2)   Whole‑Genome Linkage Scan (1)   Genome‑Wide Association Study (710)   Mitochondrial Haplogroup (36)   Mitochondrial genome (3)  
  • Variant type: + -
    SNP (572)   Locus (5)   Haplotype (87)   Other (1)   STR (11)   Deletion (5)   CNV (1)    (1)   VNTR (1)  
    • 1 2 3 4 5 6 7 8 9 10 11 12
    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types


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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    55 (L/M) PON1 0.94 0.44 308 vs 579 Italian, 296 vs 296 Irish — Irish, Italian Italian 100.8 years, Irish 89.8 years — — Candidate Region/Gene 15050299
    192 (Q/R) PON1 1.30 0.007 308 vs 579 Italian, 296 vs 296 Irish — Irish, Italian Italian 100.8 years, Irish 89.8 years Q — Candidate Region/Gene 15050299
    rs1800795 IL-6 — 0.018 285 — Finn 90-95 C G Candidate Region/Gene 15664628
    rs662 PON1 — 1.0 579 vs 308 — Italian Over 100 G A Candidate Region/Gene 12082503
    rs854560 PON1 — 1.0 579 vs 308 — Italian Over 100 — — Candidate Region/Gene 12082503
    192/55 loci PON1 — 0.01 579 vs 308 — Italian Over 100 — R+M+ Candidate Region/Gene 12082503
    codon 192 PON1 — 1.0 192 vs 77 — Italian 56 ages 66 to 89, 96 >90 — — Candidate Region/Gene 16799134
    codon 55 PON1 — 1.0 192 vs 77 — Italian 56 ages 66 to 89, 96 >90 — — Candidate Region/Gene 16799134
    192 PON1 1.26 0.007 Italian: 308 vs 579; Northern Irish: 296 vs 296 — Irish Italian: Mean age 100.8 +/- 2.1; Northern Irish: Mean age 89.8 +/- 5.7 Q — Candidate Region/Gene 15050299
    rs2228078 GHRHR 1.48 0.21 314 vs 603;279 vs 797;383 vs 363 — Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 129 — — Candidate Region/Gene 19489743
    rs6670 IGFBP3 1.02 0.75 319 vs 603;279 vs 797;383 vs 363 — Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 134 — — Candidate Region/Gene 19489743
    rs327519 PAX4 (for males) 5.70 0.004 137 vs 213 — Korean Mean age 90 — G Genome-Wide Association Study 19641380
    rs2072454, rs2293347, rs3807362, rs884225 EGFR (for females) 4.11 0.003 137 vs 213 — Korean Mean age 90 — CGCA Genome-Wide Association Study 19641380
    rs10256972 C7orf50 — 0.00224 1173 vs 570 — American 85-100 — A Genome-Wide Association Study 22533364
    rs7800926 PFTK1 1.71 0.000233438 801 vs 914 — Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs1557967 TBXAS1 1.24 0.000791168 801 vs 914 — Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs12155014 OGDH 1.12 0.00080402 801 vs 914 — Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs6946852 MEOX2 1.19 0.000659153 801 vs 914 — Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs4729049 CDK6 1.36 0.003946549 801 vs 914 — Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs3817530 UBE2H 1.40 0.000478367 801 vs 914 — Caucasian Median age 104 A C Genome-Wide Association Study 22279548
    rs11767557 EPHA1 — 0.267 1364 — American, British Age range 50-108; mean age at death 80.2 G A Candidate Region/Gene 22445811
    rs7803143 PSCD3 — 1.57e-05 1364 — American, British Age range 50-108; mean age at death 80.2 C T Genome-Wide Association Study 22445811
    rs4720752 RPA3 — 1.93e-05 1364 — American, British Age range 50-108; mean age at death 80.2 A G Genome-Wide Association Study 22445811
    rs6962026 PSCD3 — 2.07e-05 1364 — American, British Age range 50-108; mean age at death 80.2 T C Genome-Wide Association Study 22445811
    rs10085518 PSCD3 — 4.59e-05 1364 — American, British Age range 50-108; mean age at death 80.2 T C Genome-Wide Association Study 22445811
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    • 25 of 41 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

    Suggest a new study Report a database issue