Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):


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    Populations | Study Types | Variant Types



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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs479744 FOXO3 1.40 0.001 388 vs 371 535 vs 553 German mean age 98.4 years Candidate Region/Gene 19196970
    rs3019435 PARK2 1.41 0.001006354 801 vs 914 Caucasian Median age 104 C A Genome-Wide Association Study 22279548
    rs282070 MAP3K7 0.0011 288 vs 554 Calabrian 90+, median 92 G Candidate Region/Gene 22576335
    HLA-A phenotype HLA-A 1.95 0.002 201 vs 211 Chinese 22 centenarians + 179 nonagenarians (mean age 93 ±1.04) A9 A30 Candidate Region/Gene 9147371
    rs4880 SOD2 0.91 0.002 1650 Danish All danes born in 1905 (Danish 1905 cohort) T Candidate Region/Gene 19428448
    rs11153598 NT5DC1 1.06 0.00214039 801 vs 914 Caucasian Median age 104 C A Genome-Wide Association Study 22279548
    HLA-DRB1 haplotypes HLA-DRB1 0.004 120 vs 129 Okinawan Mean age 102.3 +/- 1.9 years non-DRB1*0401 alleles DRB1*0401 Candidate Region/Gene 9389323
    rs1008438 HSPA1A 0.005 157 vs 62 Danish 92.8 A Candidate Region/Gene 16804002
    rs9456497 IGF2R 1.42 0.005 1089 vs 736 1613 vs 1104 Danish 92-93 years old A G Candidate Region/Gene 22406557
    rs1008438 HSPA1A 0.005 157 vs 62 Danish 92.8 A Candidate Region/Gene 16804002
    (A/C)−110 HSP70-1 0.40 0.005 120 vs 471 Italian 100 years and above A Candidate Region/Gene 14501185
    rs7762395 FOXO3 1.38 0.005 388 vs 371 535 vs 553 German mean age 98.4 years Candidate Region/Gene 19196970
    rs9456497 IGF2R 1.42 0.005 1089 vs 736 1613 vs 1104 Danish 92.2–93.8 (mean age 93.2) A Candidate Region/Gene 22406557
    rs3800358 BTBD9 0.00541 1173 vs 570 American 85-100 T Genome-Wide Association Study 22533364
    rs6911407 FOXO3 1.28 0.006 388 vs 371 535 vs 553 German mean age 98.4 years Candidate Region/Gene 19196970
    rs2802288 FOXO3 1.28 0.006 388 vs 371 535 vs 553 German mean age 98.4 years Candidate Region/Gene 19196970
    rs768023 FOXO3 1.27 0.007 388 vs 371 535 vs 553 German mean age 98.4 years Candidate Region/Gene 19196970
    rs12206094 FOXO3 1.38 0.0076 1089 vs 736 Danish 92–93 C Candidate Region/Gene 20849522
    rs2802292 FOXO3 1.34 0.0078 1089 vs 736 Danish 92–93 T Candidate Region/Gene 20849522
    rs1799945 HFE 0.008 57 vs 60 Italian 100-105 Candidate Region/Gene 12714263
    rs699947 VEGFA 1.43 0.008 166 vs 324 Italian 85-99 (mean 89.8±2.8) C A Candidate Region/Gene 17574707
    rs4880 SOD2 0.009 224 vs 441 Ashkenazi Jewish 75 C T Candidate Region/Gene 15621215
    rs4880 SOD2 0.009 (150 m, 74 f) vs (121 m, 320 f) Ashkenazi Jewish Mean age 75 T Candidate Region/Gene 15621215
    rs1008438 HSPA1A 0.009 894 total Italian 18-109 A C Candidate Region/Gene 16896546
    2437 T>C HSPA1L 0.01 129 vs 100 Irish 80–97 2437C Candidate Region/Gene 12742533

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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