Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):


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    Populations | Study Types | Variant Types



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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs1042719 ADRB2 1.29 1.29 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 G C Candidate Region/Gene 23020224
    rs1042714 ADRB2 0.558 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 Candidate Region/Gene 23020224
    rs6883523 GHR 1.05 0.52 311 vs 603;279 vs 797;383 vs 363 Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 126 Candidate Region/Gene 19489743
    rs4292454 GHR 1.07 0.39 309 vs 603;279 vs 797;383 vs 363 Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 124 Candidate Region/Gene 19489743
    rs28360135 XRCC4 0.29 430 vs 290 British Mean age 70 Candidate Region/Gene 16518718
    rs6887528 GHR 1.19 0.25 312 vs 603;279 vs 797;383 vs 363 Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 127 Candidate Region/Gene 19489743
    rs12696304 TERC 0.248 1013 total Danish Candidate Region/Gene 22136229
    rs4866941 GHR 1.11 0.19 310 vs 603;279 vs 797;383 vs 363 Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 125 Candidate Region/Gene 19489743
    rs1042713 ADRB2 0.149 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 Candidate Region/Gene 23020224
    rs2053044 ADRB2 0.138 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 Candidate Region/Gene 23020224
    rs3764451 GHR 0.86 0.094 308 vs 603;279 vs 797;383 vs 363 Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 123 Candidate Region/Gene 19489743
    rs12153009 GHR 0.87 0.033 305 vs 603;279 vs 797;383 vs 363 Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 120 Candidate Region/Gene 19489743
    rs326146 ADCY2 1.46 0.024 137 vs 213 Korean Mean age 90 A Genome-Wide Association Study 19641380
    rs1061581 - rs1008438 - rs2227956 Hsp70Ba 0.55 0.015 168 cases Danish Mean age 92.8 +/- 0.4 G-C-T (haplotype) Candidate Region/Gene 20388090
    rs1042718 ADRB2 1.27 0.014 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 C A Candidate Region/Gene 23020224
    rs155979 PCSK1 0.61 0.012 137 vs 213 Korean Mean age 90 G Genome-Wide Association Study 19641380
    rs2043270 FLJ31951 1.29 0.00761736 801 vs 914 Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs3772190 TERC 0.006 1013 total Danish A G Candidate Region/Gene 22136229
    rs2940935 GHR 1.24 0.0031 307 vs 603;279 vs 797;383 vs 363 Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 122 Candidate Region/Gene 19489743
    rs10055012 SEMA6A 1.20 0.001722103 801 vs 914 Caucasian Median age 104 C A Genome-Wide Association Study 22279548
    rs2940923 GHR 1.21 0.0013 306 vs 603;279 vs 797;383 vs 363 Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 121 Candidate Region/Gene 19489743
    rs262883 DOCK2 1.17 0.001201492 801 vs 914 Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs2963154 NR3C1 1.10 0.0010712 801 vs 914 Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs793017 ERGIC1 1.38 0.000595001 801 vs 914 Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs216148 CSF1R 1.45 0.000577091 801 vs 914 Caucasian Median age 104 G A Genome-Wide Association Study 22279548
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    • 25 of 34 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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