Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (607)   No Age Effect (103)  
  • Study type: + -
    Genome‑Wide Association Study « 
  • Variant type: + -
    SNP (147)   Locus (1)  
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    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types


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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs12892152 NRXN3 1.87 5.78e-05 403 vs 1670 3746 vs 5912 Dutch Mean age 94 — A Genome-Wide Association Study 21418511
    rs10483493 TTC6 1.36 5.9607e-05 801 vs 914 — Caucasian Median age 104 A C Genome-Wide Association Study 22279548
    rs10498263 OR4Q3 — 8.3e-05 1345 cohort + 1087 offspring — American — — — Genome-Wide Association Study 17903295
    rs2075773 ANGEL1 1.50 0.00043588 801 vs 914 — Caucasian Median age 104 A C Genome-Wide Association Study 22279548
    rs1076584 VASH1 1.50 0.000456922 801 vs 914 — Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs1429842 SLC25A21 1.82 0.000540019 801 vs 914 — Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs4902538 RAD51L1 1.29 0.000661578 801 vs 914 — Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs2498804 ATK1 0.75 0.001 403 vs 1670 4149 vs 7582 Dutch mean 94 A — Genome-Wide Association Study 21418511
    rs1033686 RAD51L1 1.30 0.002359037 801 vs 914 — Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs8003961 DLG7 1.10 0.005011434 801 vs 914 — Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    • 10 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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