rs3803304

Polymorphism: rs3803304
rs3803304 ( SNPedia | 23andMe )

Location: 14q32.32

Factor:
- Symbol: AKT1
- Name: v-akt murine thymoma viral oncogene homolog 1
- Entrez ID: 207
- Ensembl ID: ENSG00000142208

Factors:
  • AKT1 v-akt murine thymoma viral oncogene homolog 1 ( 207 / ENSG00000142208 )


  • Description:

    SNP is G/C. OR and p-value are for rare homozygous allele genotype

    Ethnicity: Caucasian
    Age of cases: Mean age 95.3; 94.5; 97.7
    Shorter lived allele: C
    Longer lived allele: G

    Statistics
    - Number of cases/controls: 294 vs 603;279 vs 797;383 vs 363 (initial)
    - Odds ratio: 0.48
    - p-value: 0.00016 [0.00016]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology: In 1st and 2nd Cohort, Two methods: template directed primer extension with fluorescence polarization detection (FP- TDI, AcycloPrime II detection kit, Perkin Elmer, Boston, MA, USA) (Hsu & Kwok, 2003) and SNPstream 48plex (Beckman Coulter, Fullerton

    Reference:
    19489743: Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity.

    Choice: Curate
    Created: July 2, 2013, 2:47 a.m.
    Updated: Aug. 8, 2014, 1:06 p.m.

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