HLA-DQB1 haplotypes

Polymorphism: HLA-DQB1 haplotypes



Location: 6p21.3

Factor:
- Symbol: HLA-DQB1
- Name: major histocompatibility complex, class II, DQ beta 1
- Entrez ID: 3119
- Ensembl ID: ENSG00000179344

Factors:
  • HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 ( 3119 / ENSG00000179344 )


  • Description:

    The frequency of HLA-DQB10503 was significantly increased in the Okinawan centenarians compared to controls. Increased frequency can be explained by a LD with DRBl1401 or vice versa, which was also significantly frequent in them, because DRB11401-DQB10503-DQA1*0104 is one of the prominent haplotypes in Okinawan Japanese.

    odds_ratio = RR = 5.196 (could not convert string to float: RR = 5.196)

    Ethnicity: Okinawan
    Age of cases: Mean age 102.3 +/- 1.9 years
    Shorter lived allele: non-DQB1*0503 alleles
    Longer lived allele: DQB1*0503

    Statistics
    - Number of cases/controls: 120 vs 129 (initial)
    - p-value: 0.0002 [0.0002]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology:

    Reference:
    9389323: Molecular genetic studies on DNA polymorphism of the HLA class II genes associated with human longevity.

    Choice: Curate
    Created: July 1, 2013, 1:04 p.m.
    Updated: Aug. 8, 2014, 1:05 p.m.

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