HFE C282Y

Polymorphism: HFE C282Y



Location: 6p21.3

Factor:
- Symbol: HFE
- Name: hemochromatosis
- Entrez ID: 3077
- Ensembl ID: ENSG00000010704

Factors:
  • HFE hemochromatosis ( 3077 / ENSG00000010704 )


  • Description:

    Women carriers of C282Y mutation are at a higher frequency among the elderly compared with control women. Possession of C282Y allele, known to be associated with an increase of iron uptake, significantly increases women possibility to reach longevity [11857056].

    Age of cases: 91-105 (< 50 versus >90)
    Shorter lived allele: C
    Longer lived allele: Y

    Statistics
    - Number of cases/controls: 35 vs 106 (initial)
    - p-value: 7.2e-07 [7.2e-07]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology: PCR & gel electropheresis

    Reference:
    11857056: Association between the MHC class I gene HFE polymorphisms and longevity: a study in Sicilian population.

    Choice: Curate_Johnny
    Created: July 1, 2013, 10:24 a.m.
    Updated: Aug. 8, 2014, 1:05 p.m.

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