−438 G/A

Polymorphism: −438 G/A



Location: 13q14.11

Factor:
- Symbol: TAFI
- Name: carboxypeptidase B2 (plasma)
- Entrez ID: 1361
- Ensembl ID: ENSG00000080618

Factors:
  • TAFI carboxypeptidase B2 (plasma) ( 1361 / ENSG00000080618 )


  • Description:

    Men with the TAFI −438 A/A genotype had decreased mortality due to all causes, and lived, on average, 0.9 more years of life, or 1.1 more years of healthy life, than men with the −438 G allele. The effects of TAFI −438 G/A in women were smaller and not statistically significant. Detailed OR information is as follows: 0.53 (0.32–0.87).

    Ethnicity: American, Caucasian
    Age of cases: 65+
    Shorter lived allele: G (men)
    Finding: Positive

    Statistics
    - Number of cases/controls: 2224 (initial)
    - Odds ratio: 0.53
    - p-value: 0.003 [0.003]
    - Significant: Yes

    Study Design
    - Classifications: No Age Effect
    - Study type: Candidate Region/Gene
    - Technology: N/A

    Reference:
    15939070: Common promoter polymorphisms of inflammation and thrombosis genes and longevity in older adults: the cardiovascular health study.

    Choice: Curate
    Created: June 30, 2013, midnight
    Updated: Aug. 8, 2014, 1:05 p.m.

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