rs11571461

Polymorphism: rs11571461
rs11571461 ( SNPedia | 23andMe )

Variant Type: SNP
Location: 12p13-p12.2

Factor:
- Symbol: RAD52
- Name: RAD52 homolog (S. cerevisiae)
- Entrez ID: 5893
- Ensembl ID: ENSG00000002016

Factors:

RAD52 RAD52 homolog (S. cerevisiae) ( 5893 / ENSG00000002016 )

Description:

In replication study- showed a non-significant tendency of association in the same direction (95% CI (OR)=[0.927–1.457])

Ethnicity: Danish
Age of cases: 92.2–93.8 (mean age 93.2)
Shorter lived allele: A
Finding: Positive

Statistics
- Number of cases/controls: 1089 vs 736 (initial) | 1613 vs 1104 (replication)
- Odds ratio: 2.226
- p-value: 0.0001 [0.0001]
- Significant: Yes

Study Design
- Classifications: Longevity-Associated
- Study type: Candidate Region/Gene

Reference:
22406557: Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies.

Choice: Curate
Created: July 2, 2013, 2:48 a.m.
Updated: Aug. 8, 2014, 1:06 p.m.

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