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Denigma
»
Lifespan
»
Variants
» Variant = A-3826G (rs1800592) - C-3740A
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Mouse Lifespan Experiments
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A-3826G (rs1800592) - C-3740A
Polymorphism:
A-3826G (rs1800592) - C-3740A
(rs1800592)
(
SNPedia
|
23andMe
)
Variant Type:
Haplotype
Location:
4q28-q31
Factor:
- Symbol:
UCP1
- Name:
uncoupling protein 1 (mitochondrial, proton carrier)
- Entrez ID:
7350
- Ensembl ID:
ENSG00000109424
Factors:
UCP1
uncoupling protein 1 (mitochondrial, proton carrier)
(
7350
/
ENSG00000109424
)
Ethnicity:
Italian
Age of cases:
>91
Shorter lived allele:
G-A
Finding:
Positive
Statistics
- Number of cases/controls:
236 vs 741 (initial)
- Odds ratio:
0.811
- p-value:
0.014 [0.014]
- Significant:
Yes
Study Design
- Classifications:
Longevity-Associated
- Study type:
Candidate Region/Gene
- Technology:
PCR
Reference:
21827845: Two variants located in the upstream enhancer region of human UCP1 gene affect gene expression and are correlated with human longevity.
Choice:
Clean
Created:
July 2, 2013, 2:48 a.m.
Updated:
Aug. 8, 2014, 1:06 p.m.
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