Checkpoint proteins control survival of the postmitotic cells in Caenorhabditis elegans.

Authors: Olsen A; Vantipalli MC; Lithgow GJ
Year: 2006
Journal: Science (New York, N.Y.)
Abstract: Checkpoints are evolutionarily conserved signaling mechanisms that arrest cell division and alter cellular stress resistance in response to DNA damage or stalled replication forks. To study the consequences of loss of checkpoint functions in whole animals, checkpoint genes were inactivated in the nematode C. elegans. We show that checkpoint proteins are not only essential for normal development but also determine adult somatic maintenance. Checkpoint proteins play a role in the survival of postmitotic adult cells.
Reference

Integration:

Created on Nov. 5, 2012, 5:58 p.m.
Not linked
Integrated: False

No notes
Species: Nematode

Experiments: 0
Interventions:

cdc-25.3 RNAi

cdc-25.1 RNAi

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