The spe-10 mutant has longer life and increased stress resistance.
Authors: Cypser JR; Johnson TE Year: 1999 Journal: Neurobiology of aging Abstract: We investigated the life span of spe-10 mutant nematodes. We also tested resistance of spe-10 mutants to ultraviolet (UV) light, heat, and paraquat and examined the relationship between resistance to UV light and the fertility defect of these animals. The spe-10 mutation significantly increased mean life span. Additionally, the mutation significantly increased resistance to both UV light and to heat. Resistance to paraquat was not significantly different from that of wild-type, nor were any dauers formed at 27 degrees C. No significant correlation was found between the UV resistance and the fertility defect, nor was the UV resistance attributable to a hormetic effect. These results reinforce the importance of stress resistance in specifying increased life span and indirectly suggest that this fertility defect is not a direct cause of life span extension. Reference
Integration:
Created on Nov. 5, 2012, 5:58 p.m. Not linked Integrated: False
Comment on This Data Unit