Perturbation of mitochondrial complex V alters the response to dietary restriction in Drosophila.

Authors: Bahadorani S; Hur JH; Lo T Jr; Vu K; Walker DW
Year: 2010
Journal: Aging cell
Abstract: Studies in a broad spectrum of model organisms have reported that dietary restriction (DR) is associated with an increase in mitochondrial electron transport chain (ETC) function. However, the question of whether ETC function is required for DR-mediated longevity remains controversial. Here, we report that genetic and pharmacological interventions that target mitochondrial complex V affect Drosophila lifespan in a nutrient-dependent manner. These findings support a requirement for mitochondrial complex V in DR-mediated longevity in flies.
Reference

Integration:

Created on Nov. 6, 2012, 11:50 a.m.
Not linked
Integrated: False

No notes
Species: Fruit fly

Experiments: 0
Interventions:

Dietary restriction by 1% yeast medium

CG5389 RNAi

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