Regulation of longevity and stress resistance by Sch9 in yeast.

Authors: Fabrizio P; Pozza F; Pletcher SD; Gendron CM; Longo VD
Year: 2001
Journal: Science (New York, N.Y.)
Abstract: The protein kinase Akt/protein kinase B (PKB) is implicated in insulin signaling in mammals and functions in a pathway that regulates longevity and stress resistance in Caenorhabditis elegans. We screened for long-lived mutants in nondividing yeast Saccharomyces cerevisiae and identified mutations in adenylate cyclase and SCH9, which is homologous to Akt/PKB, that increase resistance to oxidants and extend life-span by up to threefold. Stress-resistance transcription factors Msn2/Msn4 and protein kinase Rim15 were required for this life-span extension. These results indicate that longevity is associated with increased investment in maintenance and show that highly conserved genes play similar roles in life-span regulation in S. cerevisiae and higher eukaryotes.
Reference

Integration:

Created on Nov. 6, 2012, 11:09 a.m.
Not linked
Integrated: False

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Species: Budding yeast

Experiments: 0
Interventions:

RIM15 deletion

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