155 | Supplemental Figure 2: Replicative lifespan curves of control strains sensitive to the tested stresses | ✔ | — | wild-type | — | — | 30.0 | — | 26.2 | 26.0 | 42.0 | 600 |
151 | Supplemental Figure 2: Replicative lifespan curves of control strains sensitive to the tested stresses | ✔ | — | wild-type | — | — | 30.0 | — | 26.3 | 25.0 | 48.0 | 45 |
134 | Figure 6: Deletion of AFG3 reduces cytoplasmic translation and extends life span by a Sir2-independent, Gcn4-dependent mechanism | ✘ | — | afg3 | — | — | 30.0 | — | 25.5 | 24.0 | 60.0 | 180 |
146 | Figure 6: Deletion of AFG3 reduces cytoplasmic translation and extends life span by a Sir2-independent, Gcn4-dependent mechanism | ✘ | — | afg3 | — | — | 30.0 | — | 24.2 | 24.0 | 45.0 | 100 |
183 | Figure 5: Hac1-independent resistance to tunicamycin in afg3∆ and rpl20bΔ cells | ✔ | — | wild-type | — | — | 30.0 | — | 23.2 | 24.0 | 38.0 | 40 |
171 | Supplemental Figure 4: Unsuppressed growth of afg3∆, yta12∆, and mrpl32∆ and corresponding lifespan curves | ✔ | — | wild-type | — | — | 30.0 | — | 25.8 | 24.0 | 53.0 | — |
152 | Supplemental Figure 2: Replicative lifespan curves of control strains sensitive to the tested stresses | ✘ | — | ctt1 | — | — | 30.0 | — | 24.9 | 24.0 | 47.0 | 43 |
169 | Supplemental Figure 4: Unsuppressed growth of afg3∆, yta12∆, and mrpl32∆ and corresponding lifespan curves | ✔ | — | wild-type | — | — | 30.0 | — | 23.7 | 23.0 | 60.0 | — |
165 | Supplemental Figure 3: Growth curves and lifespan curves of respiratory dead or deficient strains | ✔ | — | wild-type | — | — | 30.0 | — | 25.2 | 23.0 | 43.0 | 35 |
159 | Supplemental Figure 2: Replicative lifespan curves of control strains sensitive to the tested stresses | ✔ | — | wild-type | — | — | 30.0 | — | 24.2 | 23.0 | 51.0 | 150 |
195 | Figure 3 | Reduced vacuolar acidity causes mitochondrial dysfunction by disrupting amino acid homeostasis. | ✘ | S288c | avt1 | — | — | — | — | 23.0 | 22.5 | 45.0 | 31 |
523 | Fig. 3. Animal survival and growth | ✔ | Wistar | — | Mutation | — | — | — | 29.0 | 22.0 | 38.0 | 6 |
182 | Supplemental Figure 5: Cold incubation similarly impairs afg3∆ cell growth and longevity relative to rpl20b∆ cells | ✘ | — | yta12 | — | — | 15.0 | — | 21.2 | 22.0 | 39.0 | 79 |
181 | Supplemental Figure 5: Cold incubation similarly impairs afg3∆ cell growth and longevity relative to rpl20b∆ cells | ✘ | — | rpl20b | — | — | 15.0 | — | 21.3 | 22.0 | 34.0 | 60 |
149 | Supplemental Figure 2: Replicative lifespan curves of control strains sensitive to the tested stresses | ✔ | — | wild-type | — | — | 30.0 | — | 24.4 | 22.0 | 55.0 | 125 |
143 | Figure 6: Deletion of AFG3 reduces cytoplasmic translation and extends life span by a Sir2-independent, Gcn4-dependent mechanism | ✘ | — | gcn4 | — | — | 30.0 | — | 22.7 | 21.0 | 42.0 | 80 |
178 | Supplemental Figure 4: Unsuppressed growth of afg3∆, yta12∆, and mrpl32∆ and corresponding lifespan curves | ✘ | — | W303;afg3 | — | — | 30.0 | — | 19.6 | 21.0 | 36.0 | — |
179 | Supplemental Figure 5: Cold incubation similarly impairs afg3∆ cell growth and longevity relative to rpl20b∆ cells | ✔ | — | wild-type | — | — | 15.0 | — | 22.3 | 21.0 | 40.0 | 40 |
167 | Supplemental Figure 3: Growth curves and lifespan curves of respiratory dead or deficient strains | ✔ | — | wild-type | — | — | 30.0 | — | 25.3 | 21.0 | 40.0 | 15 |
180 | Supplemental Figure 5: Cold incubation similarly impairs afg3∆ cell growth and longevity relative to rpl20b∆ cells | ✘ | — | afg3 | — | — | 15.0 | — | 23.5 | 21.0 | 49.0 | 79 |
135 | Figure 6: Deletion of AFG3 reduces cytoplasmic translation and extends life span by a Sir2-independent, Gcn4-dependent mechanism | ✘ | — | sir2;fob1 | — | — | 30.0 | — | 19.7 | 20.0 | 40.0 | 39 |
177 | Supplemental Figure 4: Unsuppressed growth of afg3∆, yta12∆, and mrpl32∆ and corresponding lifespan curves | ✔ | — | W303 | — | — | 30.0 | — | 18.8 | 20.0 | 36.0 | — |
172 | Supplemental Figure 4: Unsuppressed growth of afg3∆, yta12∆, and mrpl32∆ and corresponding lifespan curves | ✘ | — | yta12 | — | — | 30.0 | — | 20.0 | 20.0 | 41.0 | — |
141 | Figure 6: Deletion of AFG3 reduces cytoplasmic translation and extends life span by a Sir2-independent, Gcn4-dependent mechanism | ✔ | — | wild-type | — | — | 30.0 | — | 21.2 | 20.0 | 38.0 | 98 |
133 | Figure 6: Deletion of AFG3 reduces cytoplasmic translation and extends life span by a Sir2-independent, Gcn4-dependent mechanism | ✔ | — | wild-type | — | — | 30.0 | — | 20.3 | 19.0 | 38.0 | 80 |