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Lifespan
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Interventions
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Mouse Lifespan Experiments
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Interventions
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Species:
+
-
House mouse «
Manipulation:
+
-
Gain‑of‑Function «
Knockout «
Loss‑of‑Function (1)
name
effect
species
mean
median
maximum
Ghr knockout
Ghr knockouts (the so called Laron mice) are dwarfs with significantly extended lifespan by 40-50% [
12933651
]. Ghr-/- mice are significantly longer lived as Ghr+/+ or Ghr+/- mice (by 40-50%) in both females and males [
10875265
;
19370397
]. 30% DR fails to affect overall survival, average or median long-lifespan of Growth hormone receptor knockout (GHRKO) mice and increased maximal lifespan only in females. Insulin sensitivity in GHRKO mutants is greater than in wild-type and is not further increased by DR [
16682650
]. Intermittent fasting also fails to extend the long lifespan of GHRKO mice [
19747233
]. Lifespan of mice with a deletion in the Ghr gene live almost 5 years [
21123740
]. In C57BL/6J this mutation increases life expectancy by 16 to 26% depending on gender [
12933651
] and in mice of mixed genetic background the increases amounted to 36-55% [
9371826
]. Serum levels of GH are elevated in mutant mice [
9371826
] and mutants are smaller than wild-type. IGF-1 and IGFBP-3 levels are also reduced in Ghr mutant mice [
10875265
]. The age-associated decline in memory retention is delayed in Ghr mutants [
11336996
].
Mouse
+16 to +55
—
—
1 intervention
Interventions are an extension of
GenAge
and
GenDR
.