Denigma

Interventions

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    Fruit fly « 
  • Manipulation: + -
    Diet Intervention «  Dietary Restriction (4)   Drug treatment (24)  
    • name effect species mean median maximum
    Minocycline treatment Treatment with minocycline (0.87mM) prolongs mean, median and maximum lifespan of wild-type (Oregon strain) of both genders. In females mincocycline extend mean and maximum lifespan by 57 and 78%, respectively. In males minocycline results in a mean and maximum lifespan extension by 114 and 28%, respectively [23185716]. Fly +57.1 to +114.3 — +28.1 to +78.3
    Rapamycin treatment Treatment of Drosophila imago with rapamycin induces increases of median (by 5-6%) lifespan (p < 0.01) in males and females, respectively and increase of maximum lifespan (by 33%) in females (p < 0.01) [22661237]. Low dose of LY294002 (5 microM) slightly increase the median and maximum lifespan [20017609]. Fly — +5 to +6 +33
    Wortmannin treatment Treatment of Drosophila imago with 0.5 micromolar wortmannin increases median (by 5%) and maximum (by 39%) lifespan in males (p < 0.001), but the lifespan differences in females were statistical insignificant (p > 0.05) [22661237]. Low dose of wortmannin (5 microM) slightly increase the median and maximum lifespan [20017609]. Fly — +5 +39
    Cynomorium songaricum supplementation The yang-tonifying herbal medicine cynomorium songaricum Repr. (CS) supplementation to the diet extends both the mean and the maximum lifespan of adult females, but insignificantly that of males. In females, maximum lifespan (determined by the 90th survival percentile) is increased by up to 11.4% with 10 mg/mL CS and 5.7% with both 20 and 30 mg/mL Cs. Mean lifespan is significantly extended by 15, 18 and 11% upon treatment with 10, 20, and 30 mg/mL CS, respectively (all P <0.001). Increased lifespan by CS is correlated with higher resistance to oxidative stress and starvation and lower lipid hydroxyperoxids levels as well as accompanied by beneficial effects, such as improved mating readiness, increased fecundity, and suppresion of age-related learning impairment in aged animals [22844336]. Fly +11 to +18 — +5.7 to +11.4
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    • 4 of 29 interventions
    Interventions are an extension of GenAge and GenDR.