Denigma

Interventions

  • Species: + -
    Nematode « 
  • Manipulation: + -
    Knockout «  RNA Interference «  Loss‑of‑Function (4)  
    • name effect species mean median maximum
    C48E7.2 RNAi RNA interference of C48E7.2 in adulthood results in a 26% increase in mean lifespan [17521386]. Worm +26 — —
    akt-1 RNAi RNA interference of akt-1 leads to lifespan extension [15998808]. Worm — — —
    aco-2 RNAi RNA interference of aco-2 leads to lifespan extension [15998808]. Worm — — —
    cco-1 RNAi RNA interference of cco-1 results in a 45-61% increase in mean lifespan (in fer-15; fem-1 and N2 background, respectively) [16103914]. RNAi against cco-1 increases mean and maximum lifespan by 73% and 90%, respectively [12471266]. cco-1 RNAi extends mean and maximum lifespan by 41 and 50%. RNAi of cco-1 during the larval stages is necessary and sufficient for increased lifespan, while only during the adulthood it fails to to extend lifespan. cco-1 RNAi results in reduced pharyngeal pumping, defecation, motility, and body size as well as reduced ATP levels (by 60-80%) and oxygen consumption. daf-16 mutation fails to prevent lifespan extenison by RNAi of cco-1 and mutation of daf-2 further extends the lifespan of cco-1 RNAi animals [12447374]. RNAi of cco-1 only during the adulthood increases mean and 75th %ile lifespan by 22-32 and 16-33%, respectively [22560223]. Worm +22 to +73 — +50 to +90
    • 4 interventions
    Interventions are an extension of GenAge and GenDR.