Interventions

  • name effect species mean median maximum
    YPC1 deletion Deletion of YPC1 decreases replicative lifespan by 15% in the alpha strain [19030232]. Yeast -15
    YPK1 deletion Deletion of YPK1 decreases replicative lifespan by 20% in the alpha strain [18340043]. Yeast -20
    YVH1 deletion Deletion of YVH1 increases replicative lifespan by 50% in the alpha strain [18340043]. Yeast +50
    Resveratrol supplementation Resveratrol significantly extends the lifespan [12939617]. Yeast
    OSH3 overexpression Overexpression of OSH3 with the promoter of VAC8 shortens mean replicative lifespan ad promotes vacuolar fusion [Xia et al. unpublished]. Yeast
    OSH3 deletion Mean replicative lifespan of OSH3 deletion mutant is not significant different from wild type [Fusheng, unpublished]. Yeast
    OSH6 mutation The CC domain of Osh6 is dispensable for longevity. Deletion of the CC domain leads Osh6 to the late endosome [Fusheng Tang, personal communication]. Yeast
    OSH7 mutation Deletion of the CC domain of Osh7 ((Perg6-OSH7-ORD) greatly shortens the lifespan [Tang et al., personal communication]. Yeast
    PEP4 overexpression Yeast
    GAD1 deletion GAD1 deletion extends replicative lifespan [21371425]. Yeast
    UGA4 deletion Deletion of UGA4 does not effect replicative lifespan [21371425]. Yeast
    CTF8 deletion Deletion of CTF8 increases mean chronological lifespan by 15-92% (15, 18, 42, 45, 92) in diploid cells [21447998]. Yeast +15 to +92
    BMH2 overexpression Overexpressing 14-3-3 protein, Bmh2, significantly extends median chronological lifespan by activating stress response [19805817]. Yeast
    LEU3 deletion LEU3 deletion dramatically increases chronological lifespan [19302372]. Yeast
    YSC84 deletion Deletion of YSC84 increases replicative lifespan by 20% in the alpha strain [19030232]. YSC84 deletion increases replicative lifespan by 25% in the alpha strain [18340043]. Yeast +20 to +25
    YPT6 deletion Deletion of YPT6 increases replicative lifespan by 20% [19030232]. YPT6 deletion increases replicative lifespan by 30% in the alpha strain and by 10% in the a strain [18340043]. Yeast +10 to +30
    YME1 deletion Deletion of YME1 decreases chronological lifespan by 50% [17492370] as well as replicative lifespan by 45% in the alpha strain [18340043]. Yeast -45 to -50
    YDC1 overexpression YDC1 overexpression decreases chronological lifespan by 40% [19059240]. Yeast -40
    VHS1 deletion Deletion of VHS1 increases replicative lifespan [16293764]. VHS1 deletion increases replicative lifespan by 60% in the alpha strain [19030232]. Yeast +60
    VAM3 deletion Deletion of VAM3 decreases mean replicative lifespan by 56% both on AL [19030232] and on moderate DR [18690010] (in BY4742/alpha strain). Yeast -56
    TMA19 deletion Deletion of TMA19 increases median replicative lifespan by 16% (P<0.02) [16806052]. TMA19 deletion increases mean replicative lifespan by 25-30% in the alpha and a strains [19030232]. Yeast +25 to +30 +16
    TIF4631 deletion Deletion of TIF4631 increases replicative lifespan by 20% in the alpha and a strains [18340043]. TIF4631 increases replicative lifespan by 10-20% in the alpha and a strains [19030232]. Yeast +10 to 20
    TIF1 deletion Deletion of TIF1 increases replicative lifespan by 20% in the alpha strain [19030232]. TIF1 deletion increases by 30% in the alpha strain and 15% in the a strain [18340043]. Yeast +15 to +30
    SWF1 deletion Deletion of SWF1 decreases replicative lifespan by 30% in the alpha strain [19030232; 18340043]. Yeast -30
    RPS6B deletion RPS6B deletion increases mean replicative lifespan by about 30% [16293764]. Deletion of RPS6B, but not of the RPS6A paralog increases replicative median lifespan robustly by 45% [17174052]. Yeast +30 +45
    Interventions are an extension of GenAge and GenDR.