| elo-1 RNAi | elo-1 RNAi in the adulthood extends lifespan by 11% [21386131]. | Worm | — | +11 | — |
| elo-2 RNAi | elo-1 RNAi in the adulthood extends lifespan by 8% [21386131]. | Worm | — | +8 | — |
| fat-4 RNAi | fat-4 RNAi in the adulthood extends lifespan by 25% [21386131]. | Worm | — | 25 | — |
| fat-3 RNAi | fat-3 RNAi in the adulthood extends lifespan by 10-15% [19301819]. | Worm | — | 10-15 | — |
| aak-2 mutation | aak-2(ok524) knockout mutants have a 12% and 18% shorter mean and maximum lifespan, respectively as well as faster age-dependent accumulation of a lipofuscin-like fluorescent pigment in the intestine [15574588]. aak-2 mutation suppresses lifespan extension and delay of the decline in locomotor activity resulting from sDR [17900900]. aak-2 mutation cancels out the lifespan extension effect of sDR and PD, regardless of the concentration of bacteria or peptones. bDR significantly extends lifespan of aak-2 mutants, but to lesser extent than that of wild-type. eat-2 mutation extends the lifespan of aak-2 mutants to the same extent than that of wild-type. Resveratrol does not increase lifespan of aak-2 mutants [19239417]. daf-2(m577);aak-2(ok524) double mutant has a lifespan that is indistinguishable from those of aak-2(ok524) single mutant [15574588]. | Worm | -12 | — | -18 |
| aak-2 overexpression | Transgenic animals with a higher aak-2 gene dose live on average 13% longer with a maximum lifespan extension on up to 25% [15574588]. | Worm | +13 | — | +25 |
| High-temperature pulse (HTP) | High-temperature pulse (HTP), an environmental stress that lowers enegery levels, extends lifespan and lowers fertility in an aak-2-dependent manner. 1-h-old wild-type adults exposed to an HTP of 35 degree Celsius for 2h live around 30% longer (mean +28; maximum +26). The same treatment dows not affect lifespan of aak-2(ok524) mutants [15574588]. | Worm | +28 | — | +26 |
| Hormesis | Lifespan can be extended by a sublethal dose of a stressor in early life. In C. elegans treatment early in life with a pusle of high temperature, high oxygen pressure, or oxidative stress extends lifespan [Cypser and Johnson 2002]. Exposure to high temperature, starvation, or mitochondrial poisoning causes an increase in the AMP/ATP ratio [11707916]. | Worm | — | — | — |
| age-2 mutation | Homocygous age-2 mutation increases mean (+43%, +31%, +38%) and maximum (+29%, +36%, +18%)) lifespan by about 20%. age-2 mutant exhibit normal motility, slightly higher swimming rates, reduced fertility and somewhat longer development times and slightly larger size at the first egg laying. Lifespan is extended by reducing the initial mortality rate. age-2 mutation complements other aging gene mutations such as age-1, daf-2, spe-26, clk-1, clk-3 and gro-1. A age-1 age-2 double mutant lives longer than animals with individual mutations and exhibits a longer lifespan at 25 degree Celsius than at 20 degree Celsius [10219000]. | Worm | +20 | — | +20 |
| apr-1 RNAi | apr-1 RNAi in the adulthood extends the lifespan [99999999]. | Worm | — | — | — |
| Germline Ablation | Germline ablation increases mean and maximum lifespan by 85% and 113% [Wollam et al., 2012].
In hermaphrodite C. elegans, removing sperm and egg-producing cells extends lifespan by 50% [23239738]. | Worm | +85 | — | +113 |
| Reducing Protein Synthesis | Reduction of protein synthesis increases the lifespan [Ref in 19686215]. | Worm | — | — | — |
| Impairing Chemosensory Perception | Impaired chemosensory perception increases lifespan [Ref in 19686215]. | Worm | — | — | — |
| Impairing mitochondrial electron transport | The impairment of the mitochondrial electron transport extends lifespan [Ref in 19686215]. | Worm | — | — | — |
| Mianserin Treatment | Mianserin a serotonin receptor antagonist (used as antidepressant in humans), can increase C. elegans lifespan when given only during adulthood. Lifespan extension is reduced or abolished by mutations that affect serontonin synthesis or serotonin reuptakte at synapses [14,16]. It requires a serontonin receptor and an octopamine receptor which are both inhibited by Mianserin. Mianserin plus DR increase lifespan only by 4% more than DR alone and totally failed to extend lifepan in eat-2(ad1116) mutants. However, mianserin does not appear to reduce food intake [14]. On average, mianserin increases lifespan by 31% by an optimal dose of 50 micromolar, but had little or no effect when given at 250 micromolar. Mianserin failes to increase the lifepsna of mutants lacking serotonin synthesis enzyme TPH-1 and causes a lifespan increase of only 13% in mutant lacking serontin reuptake transporter MOD-5. Mianserin does not increase lifepan of SER-4 or SER-4 mutants. Mianserin increases lifespan by31% when given throughout adulthood, but it only result in 10% lifespan extension when it was gieven beginning at adult day 5. Mianserin also failed to increase lifespan in liquid lifespan assay and in animals grown on solid agarose plates lacking ill-defined component of commoly used agar plates (agar and Bacto peptone). Mianserin increases lifespan of animlas grown at 20 but not at 25 degree Celsius [19686215]. | Worm | — | — | — |
| 272N18 Treatment | 272N18 (3-(3-nitrophenyl)-11-phenyl-2,3,4,5,10,11-hexohydro-1H-dibenzo[b,e] [1,4]diazepin-1-one dihdrochloride) increases lifespan by 20%, bears a structural resemblance to certain human antidepressants that affect signalling by the neurotransmitter serotonin. | Worm | — | — | — |
| Mirtazapine Treatment | Treatment with mirtazapine increases lifespan by 20-30% [14 in 19686215]. | Worm | — | — | — |
| Cypoheptadine Treatment | Treatment with ypoheptadine increases lifespan by 20-30% [14 in 19686215]. | Worm | — | — | — |
| Methiothepin Treatment | Treatment with methiothepin increases lifespan by 20-30% [14 in 19686215]. | Worm | — | — | — |
| SER-1 Mutation | SER-1 mutation extends lifespan [16-18 in 19686215]. | Worm | — | — | — |
| L-proline supplementation | L-proline supplementation increases lifespan by 5.8 and 13.6% (mean and maximum lifespan) [22482728]. | Worm | +6 | — | +14 |
| snap-29 RNAi | RNAi against snap-29 starting in the adulthood decreases mean and maximum lifespan by 49 and 72%, respectively [23144747]. | Worm | -48.6 | — | -72.0 |
| F35G12.4 RNAi | RNAi against F35G12.4 starting in the adulthood decreases the lifespan [New longevity regulators]. | Worm | — | — | — |
| cdtl-7 RNAi | RNAi against cdtl-7 starting in the adulthood decreases mean and maximum lifespan by 22 and 25%, respectively [23144747]. | Worm | -22.2 | — | -25.0 |
| vha-2 RNAi | RNAi against vha-2 starting in the adulthood decreases the lifespan [New longevity regulators]. | Worm | — | — | — |
GenAge
GenDR
