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Lifespan
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Interventions
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Mouse Lifespan Experiments
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Interventions
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Species:
+
-
Podospora anserine «
Manipulation:
+
-
Mutation «
Deletion «
Loss‑of‑Function (2)
name
effect
species
mean
median
maximum
COX1 deletion
Deletion of mobile group II intron (intron alpha) from COX1 doubles lifespan and prevents accumulation of senescence-associated DNA concatemer corresponding to this of the mitochondrial genome [
10330149
]. Deletion encompassing COX1's intron alpha and its upstream exon abolishes the senescence process entirely [
2999848
].
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COX5 deletion
Disruption of the nuclear COX5 gene delays senescence, increase longevity between 7- and 15-fold (in 30 tested isolates) and the onset of senescence is not associated by accumulation of senescence-specific mtDNA molecules. COX5 deletion results in exclusive use of the alternative respiratory pathway and a decrease in production of reactive oxygen species and the prevention of the accumulation of several senescence-specific mitochondrial DNA molecules [
10759557
].
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2 interventions
Interventions are an extension of
GenAge
and
GenDR
.