Denigma

Interventions

  • Species: + -
    House mouse « 
  • Manipulation: + -
    Gain‑of‑Function «  Overexpression «  Mutation (1)   Deletion (1)   Gene Therapy (1)  
    • name effect species mean median maximum
    Nudt1 Overexpression hMTH1-Tg mice express high levels of the hMTH1 hydrolase that degrades 8-oxoGTP and 8-oxoGTP and excludess 8-oxoguanine from both DNA and RNA. hMTH1-overexpresing mice have significantly lower steady-state levels of 8-oxoguanine in both nuclear and mitochondrial DNA of several organs, including the brain. hMTH1 overexpression prevents the age-dependent accumulation of DNA 8-oxoguanine that occurs in the wild-type mice. These lower levels of oxidized guanines are associated with increased longevity and hMTH1-Tg animals live significantly longer than their wild-type littermates [23648059]. Mouse — — —
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    • 1 of 26 interventions
    Interventions are an extension of GenAge and GenDR.