Interventions

  • Species: + -
  • name effect species mean median maximum
    aak-2 overexpression Transgenic animals with a higher aak-2 gene dose live on average 13% longer with a maximum lifespan extension on up to 25% [15574588]. Worm +13 +25
    aakg-2 overexpression Overexpression of aakg-2 extends mean, median, and maximum lifespan by 47, 45, and 35% [22737090]. Worm +47 +45 +35
    abu-11 overexpression Overexpression of abu-11 extends mean lifespan by 9% to 28% [16256736]. Worm +9 to +28
    aqp-1 overexpression Overexpression of aqp-1::GFP rescues short lifespan of aqp-1 deletion mutants and partially prevented glucose from shortening lifespan. Worm
    cbp-1 overxpression Overexpression of cbp-1 does not significantly affect lifespan [19924292]. Worm
    clk-1 overexpression Overexpression of clk-1 shortens lifespan and is associated with increased mitochondrial activity [10202142]. Worm
    clk-1 overexpression Overexpression of clk-1 shortens lifespan and is associated with increased mitochondrial activity [10202142]. Worm
    Coq7 overexpression Transgenic overexpression of mouse Coq7 reverts the extended lifespan of clk-1 mutants [11511092]. Worm
    cst-1 overexpression Overexpression of cst-1 extends lifespan and delays aging in a daf-16-dependent manner [16751106]. Worm
    cup-4 overexpression cup-4 overexpession reduces oxidative stress resistance and shortens lifespan of wild-type under AL [19783783]. Worm
    daf-16 overexpression Overexpression of wild-type DAF-16 modestly increases lifespan by 20% [11747825]. Worm +20
    daf-18 overexpression Overexpression increases adult lifespan in individual tissues [16153634]. Worm
    faah-1 overexpression faah-1 overexpression reduces eicosapentaenoyl ethanolamide (EPEA), palmitoleyol ethanolamide, linoleyol ethanolamide, as well as arachidonoyl ethanolamide (AEA) levels, delays development, increases thermal stress resistance, and was associated with mean and maximum adult lifespan extension by 19 and 35%, respectively, in presence of abundant food but not under (two different protocols of) DR. Overexpression in pharynx was largely sufficient for this lifespan extension [21562563]. Worm +19 +35
    hsf-1 overexpression Overexpression of hsf-1 extends the mean, median, and maximum lifespan by 37, 35, and 29% [22737090]. Worm +37 +35 +29
    hsp-6 overexpression Overexpression of hsp-6 from a muscle-specific promoter extends lifespan mean and maximum lifespan by 43 and 45% relatively to animals expressing GFP from the same promoter [11959102]. Worm +43 +45
    INS overexpression Expression of human insulin under an inducible heat shock promoter increases nematode lifespan by 25% and is also able to enhance the lifespan of daf-2 mutants [11274053]. Worm +25
    ins-1 overexpression Increased dosage of ins-1 under its own promoter as well as a heat shock promoter increases lifespan by 25% and is also able to increase the lifespan of daf-2 mutants. Overexpression of ins-1 also causes an increase in dauer formation and can enhance the dauer formation of daf-2 mutants [11274053]. Worm +25
    jnk-1 overexpression Overexpression of jnk-1 increases lifespan by 40% [15767565; 23097426]. JNK-1 overexpression extends the lifespan in a daf-16-dependent manner. JNK-1 overexpression does not extend the lifespan of animals unable to synthesize miRNAs, i.e. pash-1(mj100) [23097426]. Worm +40
    lin-4 overexpression Overexpressing lin-4 extends lifespan [16373574]. Worm
    lmp-2 overexpression Overexpression of lmp-2 increases mean, median and, maximum lifespan by 32, 35, and 41% [22737090]. Worm +32 +35 +41
    lys-1 overexpression Overexpression of lys-1 increases mean and maximum lifespan by 5 and 26%, but has no significant effect on median lifespan [22737090]. Worm +5 +26
    lyz overexpression Overexpression of lyz increases mean, median, and maximum lifespan by 26, 30 and 44% [22737090]. Worm +26 +30 +44
    mir-239 overexpression Overexpressing mir-239 decreases mean and maximum lifespan by 13 and 17 - 33%, respectively [21129974]. Worm -13 -17 to -33
    mir-246 overexpression mir-246 overexpression increases mean and maximum lifespan by 6 and 5 - 14%, respectively [21129974]. Worm +6.3 +4.8 to +14.3
    mir-71 overexpression Gain-of-function of mir-71 increases lifespan [21129974]. Extra copies of mir-71 extend the lifespan with an increase in lifespan by 15 - 25% [22482727], Worm +15 to +25
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    • 25 of 47 interventions
    Interventions are an extension of GenAge and GenDR.