| aak-1 mutation | aak-1 does not appear to be required for the control of lifespan [15574588]. | Worm | — | — | — |
| aak-2 mutation | aak-2(ok524) knockout mutants have a 12% and 18% shorter mean and maximum lifespan, respectively as well as faster age-dependent accumulation of a lipofuscin-like fluorescent pigment in the intestine [15574588]. aak-2 mutation suppresses lifespan extension and delay of the decline in locomotor activity resulting from sDR [17900900]. aak-2 mutation cancels out the lifespan extension effect of sDR and PD, regardless of the concentration of bacteria or peptones. bDR significantly extends lifespan of aak-2 mutants, but to lesser extent than that of wild-type. eat-2 mutation extends the lifespan of aak-2 mutants to the same extent than that of wild-type. Resveratrol does not increase lifespan of aak-2 mutants [19239417]. daf-2(m577);aak-2(ok524) double mutant has a lifespan that is indistinguishable from those of aak-2(ok524) single mutant [15574588]. | Worm | -12 | — | -18 |
| aakb-1 RNAi | RNA interference of aakb-1 results in decreased lifespan and earlier accumulation of lipofuscin [16673436]. | Worm | — | — | — |
| aakb-2 RNAi | RNA interference of aakb-2 results in decreased lifespan and earlier accumulation of lipofuscin [16673436]. | Worm | — | — | — |
| aat-8 RNAi | RNA interference of aat-8 increases mean lifespan by 30% [17608836]. | Worm | +30 | — | — |
| abce-1 RNAi | abce-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| abcx-1 RNAi | RNA interferenceof abcx-1 in adulthood extends mean lifespan by 16% [17521386]. | Worm | +16 | — | — |
| abi-1 RNAi | abi-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| abs-2 RNAi | RNA interference of abs-2 leads to lifespan extension [16103914]. | Worm | — | — | — |
| acdh-1 RNAi | RNAi knockdown of acdh-1 starting at hatching or only during the adulthood significantly decreases lifespan of eat-2 without affecting wild-type lifespan [22810224]. | Worm | — | — | — |
| acdh-10 RNAi | Kncockdown of acdh-10 via RNAi started after the animal reached the late L4 stage increases mean lifespan by 8% significantly and by 3 non-significantly [22103665]. | Worm | — | — | — |
| acdh-12 RNAi | Knockdown of acdh-12 via RNAi started after the animal reached the late L4 stage has no significant effect on mean lifespan [22103665]. | Worm | — | — | — |
| acdh-12 RNAi | RNA interference of acdh-12 starting at hatching or only during the adulthood significantly decreases eat-2 lifespan without affecting the lifespan of wild-type [22810224]. | Worm | — | — | — |
| acdh-3 RNAi | Knockdown of acdh-3 via RNAi started after the animal reached the late L4 stage has no significant effect on mean lifespan [22103665]. | Worm | — | — | — |
| acl-11 RNAi | RNA interference of acl-11 leads to lifespan extension [12447374]. | Worm | — | — | — |
| aco-2 RNAi | Knockdown of aco-2 via RNAi started after the animal reaches the L4 stage extends mean and maximum lifespan by 9-14% and 9%, respectively [22103665]. | Worm | +9 to +14 | — | +9 |
| aco-2 RNAi | RNA interference of aco-2 leads to lifespan extension [15998808]. | Worm | — | — | — |
| acs-4 RNAi | Knockdown of acs-4 via RNAi started after the animal reached the late L4 stage appeared not significant affect on lifespan (although there was a slight non-significant increase by 5% in mean lifespan). However the same study found also a significant increase in mean lifespan by 6-9% in further experiments [22103665].
| Worm | +5 to 9% | — | — |
| acs-5 RNAi | RNA interference of acs-5 increases mean lifespan by 52% [17608836]. | Worm | +52 | — | — |
| act-4 RNAi | Knockdown of act-4 started after the animal reached the late L4 stage decreases mean lifespan by 28% [22103665]. | Worm | — | — | — |
| age-1 mutation | Recessive knockout mutants of age-1 have a 40-65% increase in mean lifespan and a 65-110% increase in maximum lifespan [8608934; 8700226]. age-1(mg44) zygotic null mutants have a mean (99%) and maximum (117%) lifespan extension [18828672]. Even in axenic culture lifespan of age-1 is extended up to 100%. age-1 mutation significantly extends lifespan under AL, but only slightly under sDR [16720740].
age-1 mutants are dauer constitutive [8056303] and display lower brood size as well as increased embryonic lethality [9504918]. Additionally, age-1 mutants have elevated levels of superoxidase dismutase and catalase activities [8389142]. | Worm | +99 | — | +117 |
| age-1 RNAi | RNAi against age-1 extends lifespan by 30% [8700226; 8608934]. age-1 RNAi increases mean and maximum lifespan by 36-46% and 48-50% [12447374]. RNAi against age-1 increases mean lifespan by 83% [18828672]. age-1(mg44) zygotic null mutants have a mean (99%) and maximum (117%) lifespan extension [18828672]. | Worm | +36 to +99 | — | +48 to +117 |
| agmo-1 RNAi | RNA interference of agmo-1 decreases median lifespan by 30% in wild type animals and 60% in daf-2 mutants [18006689]. | Worm | — | -30 | — |
| ain-1 RNAi | RNA interference of ain-1 decreases median lifespan by 10% in wild type animals, 20% in a daf-2 background and 44% in daf-2/daf-16 double mutants [18006689]. | Worm | — | -10 | — |
| akt-1 RNAi | RNA interference of akt-1 leads to lifespan extension [15998808]. | Worm | — | — | — |
GenAge
GenDR
