| baf-1 RNAi | RNA interference of baf-1 decreases median lifespan by 28% in daf-2 mutants [18006689]. | Worm | — | — | — |
| bec-1 RNAi | bec-1 is required for normal dauer morphogenesis and lifespan extension. Knockdown of bec-1 via RNA interference results in a shortened mean and maximum lifespan by 14 and 5% [12958363]. bec-1 RNAi does not significantly change the lifespan of wild-type, but completely suppresses the longevity phenotype of eat-2 mutation [17912023; 18282106] and prevents lifespan extension by daf-2(e1370) mutation [12958363]. bec-1 RNAi causes the formation of abnormal dauers in a daf-2(e1379) background [12958363]. | Worm | -14 | — | -5 |
| beta-transducin RNAi | beta-transducin RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| blmp-1 RNAi | RNA interference of blmp-1 decreases median lifespan by 17% in a daf-2 background and 20% in daf-2/daf-16 double mutants [18006689]. | Worm | — | -17 | — |
| bsk RNAi | RNA interference of bsk in intestinal stem cells, results in short lived mutants with impaired intestinal homeostasis and tissue regeneration. The mean lifespan of males is 16.4% lower and those of female is reduced by 10.2% [20976250]. | Fly | -10.2 to -16.4 | — | — |
| bub-3 RNAi | RNAi against bub-3 increases mean and maximum lifespan by 6-7% and 7%, respectively [18059442]. | Worm | +6-7 | — | +7 |
| Bub1b mutation | Bub1b mutation decreases median lifespan by 60% (from 15 to 6 months). Bub1b mutant mice develop many phenotypes suggestive of accelerated aging, including: progressive bilateral cataracts, substantial loss of sub dermal adipose tissue, spinal kyphosis, muscle atrophy, and decreased wound healing. Moreover, there is a pronounced increase in senescent associated Beta-galactosidase expression in late generation Bub1b mutant mice, indicative of increased rate of cellular senscence. Homozyogous knockout of Bub1b results in lethality, while heterozygous animals exhibit no aging phenotypes [15208629]. | Mouse | — | -60 | — |
| bus-8 RNAi | RNA interference of bus-8 decreases median lifespan by 58% in wild-type animals, 81% in a daf-2 background and 45% in daf-2/daf-16 double mutants [18006689]. | Worm | — | -58 | — |
| C01F1.1 RNAi | RNA interference of C01F1.1 decreases median lifespan by 28% in wild-type animals, 37% in a daf-2 background and 14% in daf-2/daf-16 double mutants [18006689]. | Worm | — | -27 | — |
| C06A5.1 RNAi | RNA interference of C06A5.1 decreases median lifespan by 39% in wild type animals, 24% in a daf-2 background and 71% in daf-2/daf-16 double mutants [18006689]. | Worm | — | -39 | — |
| C07A9.2 RNAi | RNA interference of C07A9.2 decreases median lifespan by 26% in wild type animals, 37% in a daf-2 background and 15% in daf-2/daf-16 double mutants [18006689]. | Worm | — | -27 | — |
| C09B7.2 RNAi | RNA interference of C09B7.2 extends lifespan [15998808]. | Worm | — | — | — |
| C11H1.3 RNAi | RNA interference of C11H1.3 decreases median lifespan by 10% in wild type animals, 14% in a daf-2 background and 41% in daf-2/daf-16 double mutants [18006689]. | Worm | — | -10 | — |
| C14A4.11 RNAi | C14A4.11 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| C14A4.14 RNAi | C14A4.14 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| C14A4.9 RNAi | RNA interference of C14A4.9 decreases median lifespan by 14% in wild type animals and 41% in daf-2 mutants [18006689]. | Worm | — | -14 | — |
| C15H9.9 RNAi | RNAi against C15H9.9 started after the animal reaches the late L4 stage decreases mean lifespan by 6-7% [22103665]. | Worm | -6 to -7 | — | — |
| C16C10.2 RNAi | C16C10.2 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| C18E9.10 RNAi | RNA interference of C18E9.10 results in lifespan extension [15998808]. | Worm | — | — | — |
| C18E9.4 RNAi | RNAi of C18E9.4 starting at L1 results in mean and median lifespan extension by about 4 and 8% [15998808]. | Worm | +4 | +8 | — |
| C26B0.3 RNAi | RNA interference of C26B0.3 decreases median lifespan by 12% in wild type animals, 68% in a daf-2 background and 17% in daf-2/daf-16 double mutants [18006689]. | Worm | — | -12 | — |
| C27B7.7 RNAi | RNA interference of C27B7.7 extends lifespan [15998808]. | Worm | — | — | — |
| C29F9.1 RNAi | RNA interference of C29F9.1 decreases median lifespan by 35% in daf-2 mutants [18006689]. | Worm | — | — | — |
| C29F9.2 RNAi | RNA interference of C29F9.2 decreases median lifespan by 12% in wild type animals and 36% in daf-2 mutants [18006689]. | Worm | — | -12 | — |
| C32H11.1 RNAi | RNA interference of C32H11.1 extends lifespan [12845331]. | Worm | — | — | — |
GenAge
GenDR
