Interventions

  • name effect species mean median maximum
    CAT5 deletion Deletion of CAT5 decreases chronological lifespan by up to 50% [17492370] and also decreases replicative lifespan by 30% in the alpha strain [18340043]. Yeast -30 to -50
    CCR4 deletion Deletion of CCR4 increases mean chronological lifespan by 20 - 41% (20, 33, 41) in diploid cells [21447998]. In W303R CCR4 deletion shortens replicative lifespan by approximately 80% and results in temperature sensitivity that is suppressed by SSD1-V. SSD1-V partially suppresses the short-lifespan of ccr4 mutant. CCR4 mutation is synthetically lethal in combination with deletion of MPT5 in the absence of SSD1-V [11805047]. Yeast -80 to +20
    CCS1 deletion Deletion of CCS1 reduces replicative lifespan by 50% [17460215]. Yeast -50
    Cdkn1a knockout Deletion of Cdkna1 (alias p21) prolongs the lifespan of telomerase-deficient mice with dysfunctional telomeres and improves the repopulation capacity and self-renewal of hematopoietic stem cells [17143283]. The p21(-/-) strains like the Cdkn1a(tmi/Tyj) exhibits enormous regenerative capacities as it closes ear holes similar to MRL mice [20231440; 21722344]. Mouse
    CIT2 deletion Deletion of CIT2 has no effect on replicative lifespan [10224252]. Yeast
    CLA4 deletion Deletion of CLA4 decreases replicative lifespan by 60% in the alpha strain [18340043; 19030232]. Yeast -60
    COQ3 deletion Deletion of COQ3 decreases chronological lifespan and renders cells respiratory deficient and sensitive to hydrogen peroxide [12586694]. Yeast
    CPR7 deletion Deletion of CPR7 has no effect on lifespan replicative lifespan, but increases chronological lifespan [11361336] Yeast
    CRC1 deletion Deletion of CRC1 increases replicative lifespan [16293764]. CRC1 deletion increases replicative lifespan by 25% in the alpha strain [19030232] Yeast +25
    CSR2 deletion Deletion of CSR2 results in higher levels of intracellular reactive oxygen species, augmentation of scavenging enzymes and extends replicative as well as chronological lifespan [16336970]. Yeast
    CTF4 deletion Deletion of CTF4 results in an approximately 75% reduced mean replicative lifespan [12024027]. Yeast
    CTF8 deletion Deletion of CTF8 increases mean chronological lifespan by 15-92% (15, 18, 42, 45, 92) in diploid cells [21447998]. Yeast +15 to +92
    CUP9 deletion Deletion of CUP9 increases replicative lifespan by 30% in the alpha and a strains [18340043]. Although CPU9 was identified as a potential long-lived mutant strain in a bar-code screen, the chronological lifespan of CUP9 deletion mutant is not significantly different from than of wild-type under starvation/extreme DR [20657825]. Yeast
    CYT1 deletion Deletion of CYT1 increases replicative lifespan by 15% in the alpha strain and decreases replicative lifespan by 20% in a strain. Deletion of CYT1 decreases replicative lifespan and cancels out replicative lifespan extension by HAP4 overexpression. Initially, it was shown that deletion of CYT1 also prevents lifespan extension by 0.5% glucose restriction [12124627], but later it was shown that either 0.5 or 0.05 % glucose restriction increases replicative lifespan of cyt1Delta cells [16311627]. Yeast
    DIF1 deletion Deletion of DIF1 decreases replicative lifespan by 20% in the alpha strain [19030232]. Yeast -20
    DNM1 deletion Deletion of DNM1 extends significantly mean and maximum lifespan by 49 and 111% in FY10 strain and by 15 and 12% in BY4741 strain [17173038]. Yeast +15 to +49 +12 to +111
    ERG3 deletion Deletion of ERG3 decreases replicative lifespan under AL, cancels out replicative lifespan extension of 0.5% glucose DR and results under DR also into a shorter replicative lifespan than under AL [18690010]. Yeast
    ERG5 deletion Deletion of ERG5 decreases replicative lifespan by 35% in the a strain [18340043], but increases mean chronological lifespan by 26 - 116% (26, 40, 43, 62, 116) in diploid cells [21447998]. Deletion of ERG5 cancels out the replicative lifespan extension of 0.5% glucose restriction [18690010]. Yeast -35 to +116
    ERG6 deletion Deletion of ERG6 cancels out replicative lifespan extension of 0.5% glucose DR and results under DR also into a shorter replicative lifespan than under AL [18690010]. Yeast
    FAR11 deletion Deletion of FAR11 significantly reduces mean chronological lifespan under starvation/extreme DR relatively to wild-type [20657825]. Yeast
    FAR3 deletion Deletion of FAR3 significantly reduces mean chronological lifespan under starvation/extreme DR relatively to wild-type [20657825]. Yeast
    FBP1 deletion Deletion of FBP1 increases survival during the first 15 days during chronologocal aging, but does not increase chronological lifespan. FBP1 deletion reduces production of reactive oxygen species [16199065]. Yeast
    FCY1 deletion Deletion of FCY1 does non-significantly decrease mean and maximum replicative lifespan by 4% and 8%, respectively [20550517]. Yeast +4 +8
    FIS1 deletion Deletion of FIS1 prolongs significantly mean and maximum lifespan by 13 and 29% as well as improves the fitness of old mother cells (in BY4741) [17173038]. Yeast +13 +29
    FKH1 FKH2 deletion Deletion of FKH1 or FKH2 has no effect on neither replicative, nor chronological lifespan [18225956]. Deletion of both FKH1 and FKH2 reduces mean chronological lifespan by 50% and abrogates lifespan extension and increased stress resistance conferred from water starvation (extreme DR). Modest increase in FKH1 or FKH2 expression results in a slight increased chronological and replicative lifespan as well as stress resistance [22438832]. Yeast
    Interventions are an extension of GenAge and GenDR.