| Vitamin C treatment | Treatment with 1 mM vitamin C has no effect on lifespan of wild-type, but significantly shortens the lifespan of both isp-1 and muo-6 mutants [21151885].
Supplementation with vitamin C normalizes the median lifespan of wnr-1 and mir-124 mutants, which both exhibit premature aging [23075628]. | Worm | — | — | — |
| vit-5 RNAi | RNA interference against vit-5 extends mean lifespan by 10-22%. vit-5 is differentially transcribed in daf-16 and daf-2 RNAi animals [12845331]. RNAi knockdown of vit-5 starting at hatching or only during the adulthood significantly extends lifespan of wild-type, but does not alter, or even shortens the lifespan of eat-2 mutants [22810224]. | Worm | +10 to +22 | — | — |
| vit-2 RNAi | vit-2 RNA interference extends mean lifespan by 21-24% [12845331]. | Worm | +21 to +24 | — | — |
| vit-1 RNAi | vit-1 RNAi animals have a mean lifespan that 103.3% of controls, but not significant different [12845331]. | Worm | — | — | — |
| vig-1 RNAi | vig-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| vha-2 RNAi | RNAi against vha-2 starting in the adulthood decreases the lifespan [New longevity regulators]. | Worm | — | — | — |
| vha-13 RNAi | Knockdown of vha-13 via RNAi started after the animal reached the late L4 stage does not significantly alter the lifespan [22103665]. | Worm | — | — | — |
| vab-1 RNAi | vab-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| URE2 deletion | Deletion of URE2 increase mean replicative lifespan by 21-31% in BY4742 [16293764]. URE2 deletion increases replicative lifespan increased by 20% in the alpha strain [19030232]. | Worm | +20 to +31 | — | — |
| unc-80 mutation | The unc-80(e1069) allele has no significant effect on lifespan [9789046].
unc-80 mutant displays irregular movement [4366476] | Worm | — | — | — |
| unc-79 mutation | The unc-79(e1068) allele has no significant effect on lifespan [9789046].
unc-78 mutants display irregular movement [4366476]. | Worm | — | — | — |
| unc-78 mutation | Mutation in unc-78 has no effect on lifespan [9789046].
unc-78 mutants move slowly [7190524]. | Worm | — | — | — |
| unc-78 mutation | Mutation in unc-78 has no effect on lifespan [9789046].
unc-78 mutants move slowly [7190524]. | Worm | — | — | — |
| unc-76 mutation | unc-76(e911) allele extends male lifespan by about 50%, but has no effect on hermaphrodite lifespan [10747056].
unc-76 mutants are uncoordinated [4366476]. | Worm | +50 | — | — |
| unc-7 mutation | Mutation of unc-7 has no effect on lifespan [9789046].
unc-67 mutants are uncoordinated [4366476]. | Worm | — | — | — |
| unc-64 mutation | Mutations in unc-64 result in constitutive dauer formation and increase lifespan, which is suppressed by mutations in daf-16 [10377425]. unc-64 mutation increases mean and maximum lifespan [16280150]. unc-64 mutation increased lifespan of hermaphrodites by approximately 70% and those of males by 150% [10377425; 4366476; 10747056].
unc-64 mutants are uncoordinated [4366476]. | Worm | +70 to +150 | — | — |
| unc-6 mutation | Mutation in unc-6 has no effect on lifespan [9789046].
unc-6 mutants are uncoordinated [4366476]. | Worm | — | — | — |
| unc-54 mutation | Mutation in unc-54 has no effect on lifespan [9789046].
unc-54 mutants are paralyzed [4366476]. | Worm | — | — | — |
| unc-52 RNAi | RNAi knockdown of unc-52 starting at hatching or only during the adulthood significantly decreases lifespan of eat-2 without affecting wild-type lifespan [22810224]. | Worm | — | — | — |
| unc-51 mutation | unc-51(e369) mutation reduces mean but extends maximum lifespan. unc-51(e369) mutation reduces lifespan of eat-2(ad1116) mutants to that of wild-type [18219227]. | Worm | — | — | — |
| unc-47 mutation | The unc-47(e367) allele has no significant effect on lifespan [9789046].
unc-47 mutants are uncoordinated [4366476]. | Worm | — | — | — |
| unc-46 mutation | unc-46(e177) allele has no significant effect on lifespan [9789046].
unc-46 mutants are uncoordinated [4366476]. | Worm | — | — | — |
| unc-4 mutation | Mutation in unc-4 has no significant effect on hermaphrodite lifespan [9789046]. Lifespan of unc-4(e120) males is extended relative to hermaphrodites approximately 2-fold [10747056].
unc-4 mutants are uncoordinated [4366476]. | Worm | +100 | — | — |
| unc-35 mutation | unc-35(e259) has no effect on male or hermaphrodite lifespan [10747056].
unc-35 mutants are uncoordinated [4366476]. | Worm | — | — | — |
| unc-32 mutation | unc-32 mutation extends male lifespan by about 170%, but has no effect on hermaphrodite lifespan [10747056].
unc-31 mutants are uncoordinated [4366476]. | Worm | +170 | — | — |
GenAge
GenDR
