| zyg-11 RNAi | zyg-11 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| ztf-12 RNAi | RNA interference of ztf-12 results in a shortened lifespan. ztf-12 is a target of daf-16 [16380712]. | Worm | — | — | — |
| ZK669.4 RNAi | Knockdown of ZK669.4 via RNAi started after the animal reached the late L4 stage has no significant effect on mean lifespan [22103665]. | Worm | — | — | — |
| ZK632.4 RNAi | RNAi against ZK632.4 started after the animal reaches the late L4 stage does not significantly affect lifespan in a consistent manner [22103665]. | Worm | — | — | — |
| ZK1320.9 RNAi | Knockdown of ZK1320.9 via RNAi started after the animal reached the late L4 stage increases mean lifespan significantly by 6% and non-significantly by 4% [22103665]. | Worm | — | — | — |
| ZC395.10 RNAi | ZC395.10 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| YLR460C deletion | Deletion of YLR460C decreases replicative lifespan by 30% in the alpha strain [19030232]. | Worm | -30 | — | — |
| Y47D3A.29 RNAi | RNAi against Y47D3A.29 decreases mean and maximum lifespan by 19-26% and 34% [18059442]. | Worm | -19-26 | — | -34 |
| Y46G5A.6 RNAi | RNA interference of Y46G5A.6 in adulthood shortens the extends lifespan of daf-2(mu150) mutants. Only a negligible or small reduction in the lifespan of wild-type worms occurs by knockdown of Y46G5A.6 [17392428]. | Worm | — | — | — |
| Y41E3.11 RNAi | Y41E3.11 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| Y37D8A.19 RNAi | Knockdown of Y37D8A.19 via RNAi started after the animal reached the late L4 stage has no significant effect on mean lifespan [22103665]. | Worm | — | — | — |
| xrn-1 RNAi | xrn-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Worm | — | — | — |
| wwp-1 RNAi | RNA interference of wwp-1 decreases median lifespan by 9% in wild-type animals and 24% in daf-2 mutants [18006689]. Loss of wwp-1 function by RNAi reduces lifespan at 25 degree Celsius, but not 20 degree Celsius. Reduced levels of wwp-1 completely suppress the extended longevity of eat-2 mutants. wwp-1 RNAi does not suppress the extended lifespan of isp-1 mutants and has only minor suppressive effects on lifespan of another mitochondrial mutant, clk-1, and in cyc-1 RNAi treated worms. RNAi depletion of wwp-1 has no effect on long lifespan of daf-2 mutants [19553937].
| Worm | — | -9 | — |
| wwp-1 overexpression | wwp-1 overexpression extends lifespan by up to 20%. RNAi reduction of pha-4, but not of daf-16 suppresses increased longevity by wwp-1 overexpression [19553937]. | Worm | — | +20 | — |
| wwp-1 mutation | Loss of wwp-1 function by mutation reduces lifespan at 25 degree Celsius, but not 20 degree Celsius. Lifespan of wwp-1 mutants across entire food concentration range by bacterial dilution in liquid culture or on solid plates does not noticeable change. Reduced levels of wwp-1 completely suppress the extended longevity of eat-2 mutants [19553937].
| Worm | — | -9 | — |
| wts-1 RNAi | RNA interference of wts-1 in adulthood extends mean lifespan by 21% [17411345]. | Worm | +21 | — | — |
| wrn-1 RNAi | RNAi kockdown of wrn-1 shortens the lifespan, increases sensitivity to DNA damage, and accelerates aging phenoypes [15115755]. | Worm | — | — | — |
| wrn-1 mutation | A nonfunctional wrn-1 DNA helicase decreases the lifespan [23075628].
The expression of miR-124 in whole wrn-1 mutant worms is significantly reduced [23075628].
Supplementation of vitamin C normalizes the median lifespan of wnr-1 and mir-124 mutants [23075628]. | Worm | — | — | — |
| wnk-1 RNAi | RNA interference of wnk-1 decreases lifespan by 9% and suppresses lifespan extension by eat-2 mutation [22829775]. | Worm | -9 | — | — |
| wdr-23 RNAi | RNA interference of wdr-23 in adulthood extends mean lifespan by 24% [17411345]. | Worm | +24 | — | — |
| wah-1 RNAi | wah-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. RNAi against wah-1 started after the animal reaches the late L4 stage extends mean lifespan by 7-8% [22103665]. | Worm | +7 to +8 | — | — |
| W09C5.8 RNAi | RNAi against W09C5.8 increases mean and maximum lifespan by 62% and 50%, respectively [12447374]. Lifespan extension by RNAi of W09C5.8 is not suppressed by daf-16. Loss of W09C5.8 activity via RNAi can also result in a shortened lifespan, reduced fertility and defects in mitochondrial respiratory chain function [19074434].
W09C5.8 RNAi animals have lower ATP content and oxygen consumption [12447374]. | Worm | +62 | — | +50 |
| vps-37 RNAi | RNA interference of vps-37 decreases median lifespan by 44% in wild-type animals, 47% in a daf-2 background and 33% in daf-2/daf-16 double mutants [18006689]. | Worm | — | +44 | — |
| vps-33.1 RNAi | RNA interference of vps-33.1 decreased median lifespan 30% in daf-2 mutants and 15% in a wild-type background [18006689]. | Worm | — | -30 | — |
| vps-22 RNAi | RNA interference of vps-22 decreases median lifespan by 43% in wild type animals, 33% in a daf-2 background and 9% in daf-2/daf-16 double mutants [18006689]. | Worm | — | -43 | — |
GenAge
GenDR
