| daf-3 mutation | daf-3(mgDf90) mutation decreases mean lifespan by 0-16% and maximum lifespan by up to 9-21%. daf-3(mgDf90) decreases mean lifespan even by 19% [17900898]. Mutation of daf-3 results in a wild-type lifespan, but greatly extends the lifespan of the long-lived daf-9 mutant [11782415]. daf-3 mutations are dauer defective. | Worm | 0 to -19 | — | -9 to -21 |
| spg-7 RNAi | Kockdown of spg-7 via RNAi started after the animal reached the late L4 stage has no significant effect on mean lifespan [22103665]. RNA interference of spg-7 in adulthood results in a 23% increase in mean lifespan [17411345]. | Worm | 0 to +23 | — | — |
| arf-3 RNA | RNA interference of arf-3 does not affect lifespan of wild-type but suppresses lifespan extension by isp-1 mutation [22829775]. | Worm | 0 | — | — |
| alg-1 RNAi | Adult-specific knockdown of the C. elegans argonaute-like gene 1 *alg-1* results in shortened lifespan with a reduction in the mean and maximum lifespan by 9 - 16% and 14%, respectively [21810936]. | Worm | -9.6 to -16.1 | — | -13.7 |
| wnk-1 RNAi | RNA interference of wnk-1 decreases lifespan by 9% and suppresses lifespan extension by eat-2 mutation [22829775]. | Worm | -9 | — | — |
| gsa-1 RNAi | RNAi against gsa-1 decreases mean and maximum lifespan by 83-85% and 48%, respectively [18059442]. | Worm | -83-85 | — | -48 |
| mpk-1 RNAi | RNAi against F43C1.2B (encoding mpk-1) decreases mean and maximum lifespan by 8-14% and 14%, respectively [18059442]. | Worm | -8-14 | — | -8 |
| pas-3 RNAi | RNA interference of pas-3 shortens mean lifespan by 7% and suppresses lifespan extension by isp-1 mutation [22829775]. | Worm | -7 | — | — |
| gdi-1 RNAi | RNAi against gdi-1 started after the animal reaches the late L4 stage decreases mean lifespan by 6-7% [22103665]. gdi-1 RNAi decrease median lifespan by 34% in daf-2 mutants [18006689]. | Worm | -6 to -7 | — | — |
| C15H9.9 RNAi | RNAi against C15H9.9 started after the animal reaches the late L4 stage decreases mean lifespan by 6-7% [22103665]. | Worm | -6 to -7 | — | — |
| bra-1 mutation | bra-1(nk1) mutation reduces mean lifespan by 6-25% [17900898]. | Worm | -6 to -25 | — | — |
| cpf-2 RNAi | RNA interference of cpf-2 decreases mean lifespan by 6% and suppresses lifespan extension by eat-2 mutation [22829775]. | Worm | -6 | — | — |
| ucp-4 overexpression | Overexpression reduces mean lifespan by 5%, has no significant effect on median lifespan, and slighlty increases maximum lifespan by 12% [22737090]. | Worm | -5 | — | +12 |
| snap-29 RNAi | RNAi against snap-29 starting in the adulthood decreases mean and maximum lifespan by 49 and 72%, respectively [23144747]. | Worm | -48.6 | — | -72.0 |
| bar-1 mutation | BAR-1 may play a role in regulating daf-16 during dauer formation, particularly in conditions of oxidative stress as it directly interaction with DAF-16 and loss of bar-1 reduces activity of DAF-16 in dauer formation and lifespan. Deletion of bar-1 reduces mean (44%) and maximal (18%) lifespan, which is to a similar degree as seen to daf-16 mutants [15905404]. | Worm | -44 | — | -18 |
| mir-71 mutation | Loss-of-function of mir-71 decreases lifespan [21129974]. mir-71 mutants have a reduced lifespan with 40% decrease in mean lifespan. Loss of mir-71 function suppresses the long lifespan of glp-1(e2141) mutants [22482727], | Worm | -40 | — | — |
| his-46 RNAi | Knockdown of his-46 via RNAi started after the animal reached the late L4 stage decreases mean lifespan by 4% [22103665]. | Worm | -4 | — | — |
| snap-1 RNAi | snap-1 RNAi in the adulthood reduces mean and maximum lifespan by 40 and 50%, respectively [23144747]. | Worm | -39.9 | — | -50.0 |
| rab-5 RNAi | rab-5 RNAi in the adulthood reduces the lifespan by 38.0% [New longevity regulators]. | Worm | -38.0 | — | — |
| eat-7 mutation | The eat-7(ad450) allele decreases lifespan by 35% [9789046] exhibits defects in pharyngeal feeding behavior [8462849]. | Worm | -35 | — | — |
| ccr-4 RNAi | RNA interference of ccr-4 decreases median lifespan by 33% in wild type animals, 37% in a daf-2 background and 44% in daf-2/daf-16 double mutants [18006689]. | Worm | -33 | — | — |
| pash-1 mutation | pash-1 mutants have a decreased lifespan and display phenotypic and molecular signs of advantaged age earlier.
pash-1(mj100) temperature sensitive loss-of-function mutation decreases (at the permissive temperature) mean and maximum lifespan by 31 and 71%, respectively. At the restrictive temperature pash-1 mutants are slightly short-lived with a mean and maximum lifespan reduction by 13 and 54%. Lifespan of pash-1 mutants is reduced by a 24h upshift to 25 degree Celsius at the young adult stage with (36 and 78% reduction mean and maximum lifespan, respectively) [23097426].
The rescue of pash-1 expression all tissues restored almost normal lifespan. Rescue specifically in hypodermis, pharynx muscle, gut had no effect on lifespan. Rescue in body wall muscle marginal extended the lifespan, while rescue specifically in the neurons significantly restored mean but not maximum lifespan. Lifespan was also restored by combined rescue in hypodermis and muscle [23097426]. | Worm | -31 | — | -71 |
| nhr-49 RNAi | RNA interference of nhr-49 shortens lifespan by 30-40% and alters fatty acid composition [15719061]. | Worm | -30 to -40 | — | — |
| rpt-5 RNAi | RNAi against rpt-5 started after the animal reached the late L4 stage decreases mean lifespan by 30-33% [22103665]. | Worm | -30 to -33 | — | — |
| mir-64-66 mir-229(nDf63) mutation | mir-64-66 mir-229(nDf63) mutation decreases the lifespan by 30% [22482727]. | Worm | -30 | — | — |
GenAge
GenDR
