| rps-20 RNAi | Knockdown of rps-20 via RNAi started after the animal reached the late L4 stage increases mean lifespan by 10-24% with no affect on maximum lifespan [22103665]. | Worm | +10 to +24 | — | 0 |
| hmg-4 RNAi | hmg-4 RNAi in the adulthood extends mean lifespan by 7%, without an effect on maximum lifespan [23144747]. | Worm | +6.5 | — | 0 |
| asb-1 RNAi | asb-1 RNAi in the adulthood extends the mean lifespan by 7% without changing the maximum lifespan [23144747]. | Worm | +6.4 | — | 0 |
| rpb-8 RNAi | rpb-8 RNAi in the adulthood extends the mean lifespan by 6% without any apparent effect on maximum lifespan [23144747]. | Worm | +6.4 | — | 0 |
| gpd-3 RNAi | gpd-3 RNAi in the adulthood extends the mean lifespan by 5% without a change in maximum lifespan [23144747]. | Worm | +5.3 | — | 0 |
| aps-1 RNAi | aps-1 RNAi in the adulthood extends mean lifespan by 8% without any apparent effect on maximum lifespan [23144747]. | Worm | +7.9 | — | 0 |
| rsr-1 RNAi | rsr-1 RNAi in the adulthood extends the mean lifespan by 6% without an effect on maximum lifespan [23144747]. | Worm | +6.1 | — | 0 |
| mpk-1 RNAi | RNAi against F43C1.2B (encoding mpk-1) decreases mean and maximum lifespan by 8-14% and 14%, respectively [18059442]. | Worm | -8-14 | — | -8 |
| rps-0 RNAi | Knockdown of rps-0 via RNAi started after the animal reached the late L4 stage extends mean lifespan by 15-21%, but decreases maximum lifespan by 8% [22103665]. | Worm | +15 to +21 | — | -8 |
| snap-29 RNAi | RNAi against snap-29 starting in the adulthood decreases mean and maximum lifespan by 49 and 72%, respectively [23144747]. | Worm | -48.6 | — | -72.0 |
| ncbp-2 RNAi | RNAi against ncbp-2 decreases mean and maximum lifespan by 23-25% and 7%, respectively [18059442]. | Worm | -23 to -25 | — | -7 |
| daf-16 RNAi | Knockdown of daf-16 decreases mean and maximum lifespan by 50% and 54%, respectively [22509016].
RNAi against daf-16 decreases lifespan of wild-type, daf-2 or glp-1 mutants [22509016; 16530050]. daf-16 RNAi completely blocks lifespan extension by daf-2 mutation, but only partially by bDR. daf-16 RNAi attenuates protection against oxidative stress by bDR. Knockdown of daf-16 decreases mean and maximum lifespan by 50% and 54%, respectively [22509016]. daf-16 RNAi decreases mean lifespan by 27% [18828672].
| Worm | -27 to 50 | — | -54 |
| pat-3 RNAi | pat-3 RNAi in the adulthood decreases mean and maximum lifespan by 28% and 50%, respectively [23144747]. | Worm | -28.1 | — | -50.0 |
| rpt-1 RNAi | rpt-1 RNAi in the adulthood decreases the mean and maximum lifespan by 28 and 50%, respectively [23144747]. | Worm | -28.4 | — | -50.0 |
| snap-1 RNAi | snap-1 RNAi in the adulthood reduces mean and maximum lifespan by 40 and 50%, respectively [23144747]. | Worm | -39.9 | — | -50.0 |
| bec-1 RNAi | bec-1 is required for normal dauer morphogenesis and lifespan extension. Knockdown of bec-1 via RNA interference results in a shortened mean and maximum lifespan by 14 and 5% [12958363]. bec-1 RNAi does not significantly change the lifespan of wild-type, but completely suppresses the longevity phenotype of eat-2 mutation [17912023; 18282106] and prevents lifespan extension by daf-2(e1370) mutation [12958363]. bec-1 RNAi causes the formation of abnormal dauers in a daf-2(e1379) background [12958363]. | Worm | -14 | — | -5 |
| gsa-1 RNAi | RNAi against gsa-1 decreases mean and maximum lifespan by 83-85% and 48%, respectively [18059442]. | Worm | -83-85 | — | -48 |
| gei-4 RNAi | gei-4 RNAi in the adulthood reduces mean and maximum lifespan by 27 and 38% [23144747]. | Worm | -27.0 | — | -38.0 |
| hsf-1 RNAi | hsf-1 RNAi abrogates lifespan extension by daf-2(e1370) mutation, but not eat-2(ad1116) or isp-1(qm150). HSF-1, like DAF-16, is required for daf-2 mutations to extend lifespan [12750521]. RNA interference of hsf-1 suppresses normal dauer formation and life-extension due to insulin-like signaling [14668486]. hsf-1 RNAi also prevents lifespan extension by bDR. bDR significantly reduces paralysis of Q35YFP or ABeta42 transgenic animals and hsf-1 RNAi totally cancels this effect. hsf-1 RNAi attenuates lifespan extension by bDR, but only partially that of daf-2 mutation. hsf-1 RNAi attenuates protection against oxidative stress by bDR. hsf-1 expression is induced by bDR [19924292]. RNAi of hsf-1 shortens median and maximum lifespan by approximately 35%. hsf-1 RNAi animals exhibit phenotypes associated with accelerated aging (as assyed by Nomarsky microscopy) [12136014]. | Worm | — | -35 | -35 |
| Y47D3A.29 RNAi | RNAi against Y47D3A.29 decreases mean and maximum lifespan by 19-26% and 34% [18059442]. | Worm | -19-26 | — | -34 |
| pnc-1 RNAi | pnc-1 knockdown by RNAi decreases maximum lifespan by 30% [17335870]. | Worm | — | — | -30 |
| sptf-3 RNAi | RNAi against sptf-3 decreases mean and maximum lifespan by 20 - 28% and 28%, respectively [18059442]. sptf-3 RNAi in the adulthood decreases the mean and maximum lifespan by 23 and 37% [23144747]. | Worm | -20 to -28 | — | -28 to -37 |
| car mutation | Loss-of-function mutation in car results in reduction of mean lifespan by 34 - 63% and maximum lifespan by 28 - 29% [17435236]. | Fly | -34 to -63 | — | -28 to -29 |
| pcf-11 RNAi | pcf-11 RNAi in the adulthood decreases mean and maximum lifespan by 19 and 25% [23144747]. | Worm | -18.9 | — | -25.0 |
| rpn-11 RNAi | rpn-11 RNAi in the adulthood decreases mean and maximum lifespan by 19 and 25%, respectively [23144747]. | Worm | -19.3 | — | -25.0 |
GenAge
GenDR
